ENSMUSG00000062380


Mus musculus

Features
Gene ID: ENSMUSG00000062380
  
Biological name :Tubb3
  
Synonyms : Q9ERD7 / Tubb3 / tubulin, beta 3 class III
  
Possible biological names infered from orthology : Q13509
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 123411424
Gene end: 123422015
  
Corresponding Affymetrix probe sets: 10576332 (MoGene1.0st)   1415978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148662
Ensembl peptide - ENSMUSP00000071134
NCBI entrez gene - 22152     See in Manteia.
MGI - MGI:107813
RefSeq - NM_023279
RefSeq Peptide - NP_075768
swissprot - A0A1D5RM76
swissprot - Q9ERD7
Ensembl - ENSMUSG00000062380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000000059Gallus gallus
 TUBB3ENSG00000258947Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tubb6 / Q922F4 / tubulin, beta 6 class V / Q9BUF5*ENSMUSG0000000147392
P68372 / Tubb4b / tubulin, beta 4B class IVB / P68371*ENSMUSG0000003675292
Q7TMM9 / Tubb2a / tubulin, beta 2A class IIA / Q13885*ENSMUSG0000005867291
Q9CWF2 / Tubb2b / tubulin, beta 2B class IIB / Q9BVA1*ENSMUSG0000004513691
Q9D6F9 / Tubb4a / tubulin, beta 4A class IVA / P04350*ENSMUSG0000006259191
Tubb5 / P99024 / tubulin, beta 5 class I / TUBB* / P07437* / tubulin beta class I*ENSMUSG0000000152591
Tubb1 / A2AQ07 / tubulin, beta 1 class VI / Q9H4B7*ENSMUSG0000001625578
Tube1 / Q9D6T1 / epsilon-tubulin 1 / Q9UJT0* / tubulin epsilon 1*ENSMUSG0000001984532
Tubd1 / Q9R1K7 / tubulin, delta 1 / Q9UJT1*ENSMUSG0000002051322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0030182 neuron differentiation IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
Hedgehog on state
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ddx11tm1Jiml/Ddx11tm1Jiml
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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