ENSMUSG00000001525


Mus musculus

Features
Gene ID: ENSMUSG00000001525
  
Biological name :Tubb5
  
Synonyms : P99024 / Tubb5 / tubulin, beta 5 class I
  
Possible biological names infered from orthology : P07437 / TUBB / tubulin beta class I
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35833921
Gene end: 35838306
  
Corresponding Affymetrix probe sets: 10450605 (MoGene1.0st)   1416256_a_at (Mouse Genome 430 2.0 Array)   1455719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001566
Ensembl peptide - ENSMUSP00000134598
NCBI entrez gene - 22154     See in Manteia.
MGI - MGI:107812
RefSeq - NM_011655
RefSeq Peptide - NP_035785
swissprot - G3UZR1
swissprot - P99024
Ensembl - ENSMUSG00000001525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubb5ENSDARG00000037997Danio rerio
 TUBBENSG00000196230Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P68372 / Tubb4b / tubulin, beta 4B class IVB / P68371*ENSMUSG0000003675298
Q9D6F9 / Tubb4a / tubulin, beta 4A class IVA / P04350*ENSMUSG0000006259196
Q9CWF2 / Tubb2b / tubulin, beta 2B class IIB / Q9BVA1*ENSMUSG0000004513696
Q7TMM9 / Tubb2a / tubulin, beta 2A class IIA / Q13885*ENSMUSG0000005867295
Tubb3 / Q9ERD7 / tubulin, beta 3 class III / Q13509*ENSMUSG0000006238092
Tubb6 / Q922F4 / tubulin, beta 6 class V / Q9BUF5*ENSMUSG0000000147391
Tubb1 / A2AQ07 / tubulin, beta 1 class VI / Q9H4B7*ENSMUSG0000001625578
Tube1 / Q9D6T1 / epsilon-tubulin 1 / Q9UJT0* / tubulin epsilon 1*ENSMUSG0000001984533
Tubd1 / Q9R1K7 / tubulin, delta 1 / Q9UJT1*ENSMUSG0000002051323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0051225 spindle assembly IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005641 nuclear envelope lumen IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045298 tubulin complex NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0042288 MHC class I protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Neutrophil degranulation
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5tm2.1Dak,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004079 abnormal putamen morphology "malformation of the lens-shaped basal ganglion involved with control of voluntary movement in the brain" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tubb5tm2.1Dak/Tubb5tm2.1Dak,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tubb5tm2.1Dak/Tubb5tm2.1Dak,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
Show

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: Tubb5tm2.1Dak/Tubb5+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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