ENSMUSG00000062591


Mus musculus

Features
Gene ID: ENSMUSG00000062591
  
Biological name :Tubb4a
  
Synonyms : Q9D6F9 / Tubb4a / tubulin, beta 4A class IVA
  
Possible biological names infered from orthology : P04350
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 57080066
Gene end: 57087782
  
Corresponding Affymetrix probe sets: 10452295 (MoGene1.0st)   1423221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071135
NCBI entrez gene - 22153     See in Manteia.
MGI - MGI:107848
RefSeq - NM_009451
RefSeq Peptide - NP_033477
swissprot - Q9D6F9
Ensembl - ENSMUSG00000062591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubb2bENSDARG00000098591Danio rerio
 zgc:55461ENSDARG00000041723Danio rerio
 P04350ENSG00000104833Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P68372 / Tubb4b / tubulin, beta 4B class IVB / P68371*ENSMUSG0000003675299
Tubb5 / P99024 / tubulin, beta 5 class I / TUBB* / P07437* / tubulin beta class I*ENSMUSG0000000152596
Q9CWF2 / Tubb2b / tubulin, beta 2B class IIB / Q9BVA1*ENSMUSG0000004513696
Q7TMM9 / Tubb2a / tubulin, beta 2A class IIA / Q13885*ENSMUSG0000005867295
Tubb3 / Q9ERD7 / tubulin, beta 3 class III / Q13509*ENSMUSG0000006238092
Tubb6 / Q922F4 / tubulin, beta 6 class V / Q9BUF5*ENSMUSG0000000147391
Tubb1 / A2AQ07 / tubulin, beta 1 class VI / Q9H4B7*ENSMUSG0000001625579
Tube1 / Q9D6T1 / epsilon-tubulin 1 / Q9UJT0* / tubulin epsilon 1*ENSMUSG0000001984533
Tubd1 / Q9R1K7 / tubulin, delta 1 / Q9UJT1*ENSMUSG0000002051323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0033269 internode region of axon IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
Hedgehog on state
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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