ENSMUSG00000018574


Mus musculus

Features
Gene ID: ENSMUSG00000018574
  
Biological name :Acadvl
  
Synonyms : Acadvl / acyl-Coenzyme A dehydrogenase, very long chain / P50544
  
Possible biological names infered from orthology : acyl-CoA dehydrogenase very long chain / P49748
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70010183
Gene end: 70015411
  
Corresponding Affymetrix probe sets: 10387768 (MoGene1.0st)   1424184_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099634
Ensembl peptide - ENSMUSP00000018718
NCBI entrez gene - 11370     See in Manteia.
MGI - MGI:895149
RefSeq - NM_017366
RefSeq Peptide - NP_059062
swissprot - B1AR28
swissprot - P50544
Ensembl - ENSMUSG00000018574
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acadvlENSDARG00000016687Danio rerio
 ACADVLENSG00000072778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771045
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086121
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*ENSMUSG0000002954520
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733220
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*ENSMUSG0000006290819
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*ENSMUSG0000002600318
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*ENSMUSG0000000380918
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*ENSMUSG0000003196918


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009062 fatty acid catabolic process IMP
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IMP
 biological_processGO:0046322 negative regulation of fatty acid oxidation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0004466 long-chain-acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Beta oxidation of palmitoyl-CoA to myristoyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mb21d1tm1d(EUCOMM)Hmgu/Mb21d1tm1d(EUCOMM)Hmgu
Genetic Background: involves: BALB/c * C57BL/6JJcl * C57BL/6N

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Acadvltm1Vje/Acadvl+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
Show

Allelic Composition: Acadvltm1Zkhu/Acadvltm1Zkhu,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Acadvltm1Vje/Acadvltm1Vje
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018574 Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*  / complex






 

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