ENSMUSG00000062908


Mus musculus

Features
Gene ID: ENSMUSG00000062908
  
Biological name :Acadm
  
Synonyms : Acadm / acyl-Coenzyme A dehydrogenase, medium chain / P45952
  
Possible biological names infered from orthology : acyl-CoA dehydrogenase medium chain / P11310
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H3
Gene start: 153922357
Gene end: 153944632
  
Corresponding Affymetrix probe sets: 10502951 (MoGene1.0st)   1415984_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072483
Ensembl peptide - ENSMUSP00000122989
Ensembl peptide - ENSMUSP00000121714
NCBI entrez gene - 11364     See in Manteia.
MGI - MGI:87867
RefSeq - NM_007382
RefSeq Peptide - NP_031408
swissprot - D6RFD7
swissprot - D3Z2A5
swissprot - P45952
Ensembl - ENSMUSG00000062908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acadmENSDARG00000038900Danio rerio
 ACADMENSG00000117054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*ENSMUSG0000002954537
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733233
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086132
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771032
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*ENSMUSG0000003196931
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*ENSMUSG0000001857430
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*ENSMUSG0000002600329
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*ENSMUSG0000000380927


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR034180  Medium-chain specific acyl-CoA dehydrogenase
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0005978 glycogen biosynthetic process IMP
 biological_processGO:0006082 organic acid metabolic process IMP
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation ISS
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0009437 carnitine metabolic process IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0019254 carnitine metabolic process, CoA-linked IMP
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
 biological_processGO:0042594 response to starvation IMP
 biological_processGO:0045329 carnitine biosynthetic process ISO
 biological_processGO:0051791 medium-chain fatty acid metabolic process IMP
 biological_processGO:0051793 medium-chain fatty acid catabolic process ISO
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0031966 mitochondrial membrane ISO
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0070991 medium-chain-acyl-CoA dehydrogenase activity IMP


Pathways (from Reactome)
Pathway description
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062908 Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*  / complex






 

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