Manteia

ENSMUSG00000027332

Mus musculus

Features

Gene ID:	ENSMUSG00000027332

Biological name :	Ivd

Synonyms :	Isovaleryl-CoA dehydrogenase, mitochondrial / Ivd / Q9JHI5

Possible biological names infered from orthology :	isovaleryl-CoA dehydrogenase / P26440

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	E5
Gene start:	118861954
Gene end:	118882909

Corresponding Affymetrix probe sets:	10474836 (MoGene1.0st) 1418238_at (Mouse Genome 430 2.0 Array) 1449001_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028807 NCBI entrez gene - 56357 See in Manteia. MGI - MGI:1929242 RefSeq - NM_019826 RefSeq - XM_006499925 RefSeq Peptide - NP_062800 swissprot - Q9JHI5 Ensembl - ENSMUSG00000027332

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*	ENSMUSG00000029545	36
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*	ENSMUSG00000027710	33
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*	ENSMUSG00000030861	32
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*	ENSMUSG00000062908	32
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*	ENSMUSG00000026003	30
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*	ENSMUSG00000018574	30
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*	ENSMUSG00000031969	30
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*	ENSMUSG00000003809	27

Protein motifs (from Interpro)

Interpro ID	Name
IPR006089	Acyl-CoA dehydrogenase, conserved site
IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR034183	Isovaleryl-CoA dehydrogenase
IPR036250	Acyl-CoA dehydrogenase-like, C-terminal
IPR037069	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006552	leucine catabolic process	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005759	mitochondrial matrix	IEA
cellular_component	GO:0031966	mitochondrial membrane	IEA
molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	IEA
molecular_function	GO:0008470	isovaleryl-CoA dehydrogenase activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEA
molecular_function	GO:0050660	flavin adenine dinucleotide binding	IEA

Pathways (from Reactome)

Pathway description

Branched-chain amino acid catabolism

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Ift88^{tm1.1(KOMP)Vlcg}/Ift88⁺ Genetic Background: C57BL/6N-Ift88^{tm1.1(KOMP)Vlcg}/J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ift88^{tm1.1(KOMP)Vlcg}/Ift88⁺ Genetic Background: C57BL/6N-Ift88^{tm1.1(KOMP)Vlcg}/J
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Ift88^{tm1.1(KOMP)Vlcg}/Ift88⁺ Genetic Background: C57BL/6N-Ift88^{tm1.1(KOMP)Vlcg}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000027332	Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr