ENSMUSG00000031969


Mus musculus

Features
Gene ID: ENSMUSG00000031969
  
Biological name :Acad8
  
Synonyms : Acad8 / acyl-Coenzyme A dehydrogenase family, member 8
  
Possible biological names infered from orthology : acyl-CoA dehydrogenase family member 8 / Q9UKU7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 26974135
Gene end: 26999566
  
Corresponding Affymetrix probe sets: 10591947 (MoGene1.0st)   1419261_at (Mouse Genome 430 2.0 Array)   1419262_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054370
Ensembl peptide - ENSMUSP00000150728
Ensembl peptide - ENSMUSP00000123012
Ensembl peptide - ENSMUSP00000122444
Ensembl peptide - ENSMUSP00000112908
NCBI entrez gene - 66948     See in Manteia.
MGI - MGI:1914198
RefSeq - XM_017313520
RefSeq - NM_025862
RefSeq - XM_006510550
RefSeq Peptide - NP_080138
swissprot - D3YTT4
swissprot - D6RDD5
swissprot - A0A1L1SUG2
swissprot - A0A0R4J0P1
Ensembl - ENSMUSG00000031969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acad8ENSDARG00000042658Danio rerio
 ACAD8ENSGALG00000001557Gallus gallus
 ACAD8ENSG00000151498Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*ENSMUSG0000002954535
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*ENSMUSG0000006290832
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771032
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086131
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733231
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*ENSMUSG0000002600330
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*ENSMUSG0000001857428
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*ENSMUSG0000000380924


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR034178  Isobutyryl-CoA dehydrogenase
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011637 abnormal mitochondrial matrix morphology "any structural anomaly of the gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion, and contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation" [GO:0005759]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031969 Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*  / complex






 

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