ENSMUSG00000026003


Mus musculus

Features
Gene ID: ENSMUSG00000026003
  
Biological name :Acadl
  
Synonyms : Acadl / acyl-Coenzyme A dehydrogenase, long-chain
  
Possible biological names infered from orthology : acyl-CoA dehydrogenase long chain / P28330
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 66830839
Gene end: 66863277
  
Corresponding Affymetrix probe sets: 10355246 (MoGene1.0st)   1448987_at (Mouse Genome 430 2.0 Array)   1448988_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027153
NCBI entrez gene - 11363     See in Manteia.
MGI - MGI:87866
RefSeq - NM_007381
RefSeq Peptide - NP_031407
swissprot - A0A0R4J083
Ensembl - ENSMUSG00000026003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acadlENSDARG00000088357Danio rerio
 ACADLENSGALG00000002891Gallus gallus
 ACADLENSG00000115361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733230
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*ENSMUSG0000002954530
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*ENSMUSG0000003196928
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771028
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*ENSMUSG0000006290828
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086128
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*ENSMUSG0000001857427
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*ENSMUSG0000000380925


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR034179  Long-chain specific acyl-CoA dehydrogenase
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
 biological_processGO:0042758 long-chain fatty acid catabolic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0004466 long-chain-acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005283 increased unsaturated fatty acid level "greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0010028 aciduria "excretion of an acid urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026003 Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*  / complex






 

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