ENSMUSG00000003809


Mus musculus

Features
Gene ID: ENSMUSG00000003809
  
Biological name :Gcdh
  
Synonyms : Gcdh / Glutaryl-CoA dehydrogenase, mitochondrial / Q60759
  
Possible biological names infered from orthology : glutaryl-CoA dehydrogenase / Q92947
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 84886393
Gene end: 84893921
  
Corresponding Affymetrix probe sets: 10580233 (MoGene1.0st)   1448717_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105367
Ensembl peptide - ENSMUSP00000116584
Ensembl peptide - ENSMUSP00000003907
NCBI entrez gene - 270076     See in Manteia.
MGI - MGI:104541
RefSeq - NM_008097
RefSeq - NM_001044744
RefSeq Peptide - NP_001038209
RefSeq Peptide - NP_032123
swissprot - Q60759
swissprot - D3Z4I2
swissprot - A0A0A0MQ68
Ensembl - ENSMUSG00000003809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcdhaENSDARG00000037057Danio rerio
 gcdhbENSDARG00000098831Danio rerio
 GCDHENSGALG00000034917Gallus gallus
 GCDHENSG00000105607Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*ENSMUSG0000002954529
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771026
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733226
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*ENSMUSG0000001857426
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*ENSMUSG0000006290825
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086124
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*ENSMUSG0000002600324
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*ENSMUSG0000003196922


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006568 tryptophan metabolic process IEA
 biological_processGO:0006637 acyl-CoA metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
 biological_processGO:0046949 fatty-acyl-CoA biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0004361 glutaryl-CoA dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Lysine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0002931 glutaricadicuria "an accumulation of an intermediate of tryptophan catabolism in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003809 Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*  / complex






 

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