ENSMUSG00000029545


Mus musculus

Features
Gene ID: ENSMUSG00000029545
  
Biological name :Acads
  
Synonyms : Acads / acyl-Coenzyme A dehydrogenase, short chain / Q07417
  
Possible biological names infered from orthology : acyl-CoA dehydrogenase short chain / P16219
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 115110299
Gene end: 115119346
  
Corresponding Affymetrix probe sets: 10532926 (MoGene1.0st)   1460216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031524
NCBI entrez gene - 11409     See in Manteia.
MGI - MGI:87868
RefSeq - NM_007383
RefSeq Peptide - NP_031409
swissprot - Q07417
Ensembl - ENSMUSG00000029545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acadsENSDARG00000030781Danio rerio
 ACADSENSGALG00000007072Gallus gallus
 ACADSENSG00000122971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acadm / P45952 / acyl-Coenzyme A dehydrogenase, medium chain / P11310* / acyl-CoA dehydrogenase medium chain*ENSMUSG0000006290838
Ivd / Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial / P26440* / isovaleryl-CoA dehydrogenase*ENSMUSG0000002733237
Acadsb / Q9DBL1 / acyl-Coenzyme A dehydrogenase, short/branched chain / P45954* / acyl-CoA dehydrogenase short/branched chain*ENSMUSG0000003086136
Acad8 / acyl-Coenzyme A dehydrogenase family, member 8 / Q9UKU7* / acyl-CoA dehydrogenase family member 8*ENSMUSG0000003196935
Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*ENSMUSG0000002771034
Acadl / acyl-Coenzyme A dehydrogenase, long-chain / P28330* / acyl-CoA dehydrogenase long chain*ENSMUSG0000002600332
Acadvl / P50544 / acyl-Coenzyme A dehydrogenase, very long chain / P49748* / acyl-CoA dehydrogenase very long chain*ENSMUSG0000001857431
Gcdh / Q60759 / Glutaryl-CoA dehydrogenase, mitochondrial / Q92947* / glutaryl-CoA dehydrogenase*ENSMUSG0000000380931


Protein motifs (from Interpro)
Interpro ID Name
 IPR006089  Acyl-CoA dehydrogenase, conserved site
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009075  Acyl-CoA dehydrogenase/oxidase C-terminal
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR013786  Acyl-CoA dehydrogenase/oxidase, N-terminal
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity ISO
 molecular_functionGO:0004085 butyryl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of butanoyl-CoA to acetyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Y
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: AcadsHdlq8-NZB/BlNJ/AcadsHdlq8-NZB/BlNJ
Genetic Background: involves: C57BL/6J * NZB/BlNJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otcspf
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010028 aciduria "excretion of an acid urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Y
Genetic Background: involves: BALB/cByJ * CD-1

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otc+
Genetic Background: involves: BALB/cByJ * CD-1

Allelic Composition: Acadsdel-J/Acads+,Otcspf/Y
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0010953 abnormal fatty acid oxidation "anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GO:0019395]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011765 oroticaciduria "increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine" [MGI:anna]
Show

Allelic Composition: Acadsdel-J/Acads+,Otcspf/Y
Genetic Background: involves: BALB/cByJ * CD-1

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otcspf
Genetic Background: involves: BALB/cByJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029545 Acads / Q07417 / acyl-Coenzyme A dehydrogenase, short chain / P16219* / acyl-CoA dehydrogenase short chain*  / complex






 

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