MP:0000020 | scaly ears | "ears covered with shedding scales or flakes" [J:65045] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0000410 | waved hair | "hair or fur having undulations or a sinusoidal shape" [J:47620] |
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0000420 | ruffled hair | "fuzzy, irregular appearance of the hair" [J:50844] |
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Allelic Composition: Kcnq1tm3Kpfe/Kcnq1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0000574 | abnormal foot pad morphology | "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0000652 | enlarged sebaceous gland | "increased size of the sebum secreting glands of the hair shaft" [J:30249] |
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Allelic Composition: Kcnq1tm3Kpfe/Kcnq1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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MP:0001190 | reddish skin | "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038] |
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Allelic Composition: Apobtm2Sgy/Apobtm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0001195 | flaky skin | "shedding scales on the skin " [J:56641] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001201 | translucent skin | "skin that is more transparent to light than normal " [J:15108] |
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Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001208 | blistering | "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039] |
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kcnq1tm3Kpfe/Kcnq1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi Genetic Background: involves: C57BL/6N
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0001231 | abnormal basal cell layer morphology | "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apobtm2Sgy/Apobtm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
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MP:0001233 | abnormal suprabasal layer morphology | "malformed or atypical condition of the suprabasal layer of the skin" [J:56777] |
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Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0001236 | abnormal spinous layer morphology | "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001239 | abnormal granular layer morphology | "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apobtm2Sgy/Apobtm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0001240 | abnormal cornified layer morphology | "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apobtm2Sgy/Apobtm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0001874 | acanthosis | "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0002053 | decreased incidence of induced tumors | "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0002060 | abnormal skin morphology | "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Apobtm2Sgy/Apobtm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt10tm1Tmm/Krt10+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
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MP:0002992 | abnormal sebaceous lipid secretion | "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0003089 | reduced skin tensile strength | "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068] |
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Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt1tm1Tmm/Krt1+,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10+ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0003849 | greasy coat | "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0009594 | abnormal corneocyte envelope morphology | "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0009596 | abnormal stratum corneum lipid matrix formation | "altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0009600 | hypergranulosis | "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0009606 | increased keratohyalin granule size | "increased number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Krt10tm1Tmm/Krt10tm1Tmm Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt1tm1Tmm/Krt1+,Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10+ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0013373 | increased sebum secretion | "increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species" [MGI:Anna] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0013375 | abnormal sebocyte morphology | "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0013376 | abnormal sebocyte differentiation | "abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum" [MGI:Anna, PMID:19944183] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0014056 | increased sebocyte proliferation | "increase in the expansion rate of sebocytes by cell division" [MGI:Anna] |
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
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