ENSMUSG00000035557


Mus musculus

Features
Gene ID: ENSMUSG00000035557
  
Biological name :Krt17
  
Synonyms : Keratin, type I cytoskeletal 17 / Krt17 / Q9QWL7
  
Possible biological names infered from orthology : keratin 17 / Q04695
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100256217
Gene end: 100261029
  
Corresponding Affymetrix probe sets: 10391066 (MoGene1.0st)   1420193_at (Mouse Genome 430 2.0 Array)   1423227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079699
NCBI entrez gene - 16667     See in Manteia.
MGI - MGI:96691
RefSeq - NM_010663
RefSeq Peptide - NP_034793
swissprot - Q9QWL7
Ensembl - ENSMUSG00000035557
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyt1ENSDARG00000092947Danio rerio
 cyt1lENSDARG00000036832Danio rerio
 krt1-19dENSDARG00000023082Danio rerio
 krt15ENSDARG00000036840Danio rerio
 krt17ENSDARG00000094041Danio rerio
 krt91ENSDARG00000036830Danio rerio
 krt92ENSDARG00000036834Danio rerio
 krt93ENSDARG00000044976Danio rerio
 krt94ENSDARG00000044975Danio rerio
 krt95ENSDARG00000014356Danio rerio
 krt96ENSDARG00000095147Danio rerio
 krt97ENSDARG00000000212Danio rerio
 krtt1c19eENSDARG00000090268Danio rerio
 si:ch211-156l18.7ENSDARG00000022334Danio rerio
 KRT17ENSGALG00000003690Gallus gallus
 KRT17ENSG00000128422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt14 / Q61781 / Keratin, type I cytoskeletal 14 ENSMUSG0000004554578
Krt42 / Q6IFX2 / Keratin, type I cytoskeletal 42 ENSMUSG0000005365475
Krt16 / Q9Z2K1 / keratin 16 / P08779*ENSMUSG0000005379769
Krt15 / keratin 15 / P19012*ENSMUSG0000005414663
Krt19 / P19001 / Keratin, type I cytoskeletal 19 / P08727* / keratin 19*ENSMUSG0000002091160
Krt13 / P08730 / Keratin, type I cytoskeletal 13 / P13646* / keratin 13*ENSMUSG0000004404160
Krt10 / keratin 10 / P13645*ENSMUSG0000001976157
Krt12 / keratin 12 / Q99456*ENSMUSG0000002091255
Krt24 / A1L317 / Keratin, type I cytoskeletal 24 / Q2M2I5* / keratin 24*ENSMUSG0000002091352
Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*ENSMUSG0000001758849
Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*ENSMUSG0000005593748
Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*ENSMUSG0000003583147


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR018039  Intermediate filament protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031424 keratinization IGI
 biological_processGO:0045109 intermediate filament organization IGI
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0051798 positive regulation of hair follicle development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032395 MHC class II receptor activity IEA
 molecular_functionGO:0042289 MHC class II protein binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0003848 brittle hair "hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0005072 abnormal hair follicle melanin granule "anomalous pigment paricles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0010686 abnormal hair follicle matrix region morphology "any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0011195 increased hair follicle apoptosis "greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [MGI:mnk]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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