ENSMUSG00000045545


Mus musculus

Features
Gene ID: ENSMUSG00000045545
  
Biological name :Krt14
  
Synonyms : Keratin, type I cytoskeletal 14 / Krt14 / Q61781
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100203162
Gene end: 100207548
  
Corresponding Affymetrix probe sets: 10391052 (MoGene1.0st)   1423935_x_at (Mouse Genome 430 2.0 Array)   1427841_at (Mouse Genome 430 2.0 Array)   1455573_at (Mouse Genome 430 2.0 Array)   1460347_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007272
NCBI entrez gene - 16664     See in Manteia.
MGI - MGI:96688
RefSeq - NM_016958
RefSeq - NM_001313956
RefSeq - NM_001313957
RefSeq Peptide - NP_001300885
RefSeq Peptide - NP_001300886
RefSeq Peptide - NP_058654
swissprot - Q61781
Ensembl - ENSMUSG00000045545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyt1ENSDARG00000092947Danio rerio
 cyt1lENSDARG00000036832Danio rerio
 krt1-19dENSDARG00000023082Danio rerio
 krt15ENSDARG00000036840Danio rerio
 krt17ENSDARG00000094041Danio rerio
 krt91ENSDARG00000036830Danio rerio
 krt92ENSDARG00000036834Danio rerio
 krt93ENSDARG00000044976Danio rerio
 krt94ENSDARG00000044975Danio rerio
 krt95ENSDARG00000014356Danio rerio
 krt96ENSDARG00000095147Danio rerio
 krt97ENSDARG00000000212Danio rerio
 krtt1c19eENSDARG00000090268Danio rerio
 si:ch211-156l18.7ENSDARG00000022334Danio rerio
 KRT17ENSGALG00000003690Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt16 / Q9Z2K1 / keratin 16 / P08779*ENSMUSG0000005379779
Krt17 / Q9QWL7 / Keratin, type I cytoskeletal 17 / Q04695* / keratin 17*ENSMUSG0000003555770
Krt42 / Q6IFX2 / Keratin, type I cytoskeletal 42 ENSMUSG0000005365469
Krt15 / keratin 15 / P19012*ENSMUSG0000005414659
Krt13 / P08730 / Keratin, type I cytoskeletal 13 / P13646* / keratin 13*ENSMUSG0000004404157
Krt10 / keratin 10 / P13645*ENSMUSG0000001976156
Krt19 / P19001 / Keratin, type I cytoskeletal 19 / P08727* / keratin 19*ENSMUSG0000002091154
Krt12 / keratin 12 / Q99456*ENSMUSG0000002091252
Krt24 / A1L317 / Keratin, type I cytoskeletal 24 / Q2M2I5* / keratin 24*ENSMUSG0000002091350
Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*ENSMUSG0000005593745
Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*ENSMUSG0000001758845
Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*ENSMUSG0000003583144


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR018039  Intermediate filament protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007568 aging ISO
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0042633 hair cycle ISO
 biological_processGO:0045110 intermediate filament bundle assembly ISS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990254 keratin filament binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm4tm1b(EUCOMM)Liz/Prdm4tm1b(EUCOMM)Liz
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000404 reduced curvature of zigzag hairs "smaller bending arch of the zigzag hairs" [J:62217]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0000467 abnormal esophagus morphology "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/?,Tnni3ktm1Tfo/Tnni3ktm1Tfo
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001140 abnormal vaginal epithelium "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Krt14tm2Der/Krt14+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Krt14tm1Der/Krt14+,Tg(KRT14-cre/PGR)1Der/?
Genetic Background: involves: 129X1/SvJ * FVB * ICR

Allelic Composition: Krt14tm1Der/Krt14+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129X1/SvJ * FVB * ICR

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001224 abnormal keratinocyte apoptosis "aberrant programmed cell death of keratin producing cells of the epidermis" [J:64948]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm4tm1b(EUCOMM)Liz/Prdm4tm1b(EUCOMM)Liz
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Krt14tm2Der/Krt14+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004126 thin hypodermis "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Prdm4tm1b(EUCOMM)Liz/Prdm4tm1b(EUCOMM)Liz
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008538 decreased zigzag hair amount "reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0009795 epidermal spongiosis "intercellular edema within the epidermis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010202 focal dorsal hair loss "focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Krt14tm2Der/Krt14+
Genetic Background: involves: 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krt14tm1Efu/Krt14tm1Efu
Genetic Background: involves: 129/Sv

 MP:0012110 increased hair follicle number "greater number of the epidermal invaginations from which the hair shaft develops" [MGI:monikat]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
Show

Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Wlstm1.1Arte/Wlstm1.1Arte,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030529 abnormal head skin morphology "any anomaly in a zone of skin that is part of the head" [UBERON:0001084]
Show

Allelic Composition: Arpc4tm1c(EUCOMM)Wtsi/Arpc4tm1c(EUCOMM)Wtsi,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: B6.Cg-Arpc4tm1c(EUCOMM)Wtsi Krt14tm1(cre)Wbm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr