ENSMUSG00000053797


Mus musculus

Features
Gene ID: ENSMUSG00000053797
  
Biological name :Krt16
  
Synonyms : keratin 16 / Krt16 / Q9Z2K1
  
Possible biological names infered from orthology : P08779
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100246091
Gene end: 100248902
  
Corresponding Affymetrix probe sets: 10391061 (MoGene1.0st)   1448932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007280
NCBI entrez gene - 16666     See in Manteia.
MGI - MGI:96690
RefSeq - NM_008470
RefSeq - NM_001313958
RefSeq Peptide - NP_001300887
RefSeq Peptide - NP_032496
swissprot - Q3SYP5
swissprot - Q9Z2K1
Ensembl - ENSMUSG00000053797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyt1ENSDARG00000092947Danio rerio
 cyt1lENSDARG00000036832Danio rerio
 krt1-19dENSDARG00000023082Danio rerio
 krt15ENSDARG00000036840Danio rerio
 krt17ENSDARG00000094041Danio rerio
 krt91ENSDARG00000036830Danio rerio
 krt92ENSDARG00000036834Danio rerio
 krt93ENSDARG00000044976Danio rerio
 krt94ENSDARG00000044975Danio rerio
 krt95ENSDARG00000014356Danio rerio
 krt96ENSDARG00000095147Danio rerio
 krt97ENSDARG00000000212Danio rerio
 krtt1c19eENSDARG00000090268Danio rerio
 si:ch211-156l18.7ENSDARG00000022334Danio rerio
 KRT17ENSGALG00000003690Gallus gallus
 KRT16ENSG00000186832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt14 / Q61781 / Keratin, type I cytoskeletal 14 ENSMUSG0000004554581
Krt42 / Q6IFX2 / Keratin, type I cytoskeletal 42 ENSMUSG0000005365466
Krt17 / Q9QWL7 / Keratin, type I cytoskeletal 17 / Q04695* / keratin 17*ENSMUSG0000003555764
Krt15 / keratin 15 / P19012*ENSMUSG0000005414659
Krt13 / P08730 / Keratin, type I cytoskeletal 13 / P13646* / keratin 13*ENSMUSG0000004404158
Krt10 / keratin 10 / P13645*ENSMUSG0000001976155
Krt19 / P19001 / Keratin, type I cytoskeletal 19 / P08727* / keratin 19*ENSMUSG0000002091153
Krt24 / A1L317 / Keratin, type I cytoskeletal 24 / Q2M2I5* / keratin 24*ENSMUSG0000002091352
Krt12 / keratin 12 / Q99456*ENSMUSG0000002091252
Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*ENSMUSG0000005593747
Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*ENSMUSG0000001758847
Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*ENSMUSG0000003583147


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR018039  Intermediate filament protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031424 keratinization IDA
 biological_processGO:0042633 hair cycle IEA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045104 intermediate filament cytoskeleton organization IDA
 biological_processGO:0051546 keratinocyte migration IDA
 biological_processGO:0061436 establishment of skin barrier IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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