Manteia

ENSMUSG00000022209

Mus musculus

Features

Gene ID:	ENSMUSG00000022209

Biological name :	Dhrs2

Synonyms :	dehydrogenase/reductase 2 / Dhrs2

Possible biological names infered from orthology :	Q13268

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	C3
Gene start:	55222007
Gene end:	55241435

Corresponding Affymetrix probe sets:	10415163 (MoGene1.0st) 1421663_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022820 Ensembl peptide - ENSMUSP00000129115 NCBI entrez gene - 71412 See in Manteia. MGI - MGI:1918662 RefSeq - XM_011245200 RefSeq - NM_027790 RefSeq - XM_006519570 RefSeq - XM_011245198 RefSeq Peptide - NP_082066 swissprot - Q149L0 Ensembl - ENSMUSG00000022209

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dhrs4 / Q99LB2 / Dehydrogenase/reductase SDR family member 4 / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 4* / dehydrogenase/reductase 4 like 2*	ENSMUSG00000022210	53
Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1*	ENSMUSG00000030825	27
Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*	ENSMUSG00000031641	27
Bdh2 / Q8JZV9 / 3-hydroxybutyrate dehydrogenase type 2 / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*	ENSMUSG00000028167	26
Dcxr / Q91X52 / L-xylulose reductase / Q7Z4W1* / dicarbonyl and L-xylulose reductase*	ENSMUSG00000039450	24
P50171 / H2-Ke6 / H2-K region expressed gene 6 / Q92506* / HSD17B8* / hydroxysteroid 17-beta dehydrogenase 8*	ENSMUSG00000073422	24
Cbr2 / P08074 / Carbonyl reductase [NADPH] 2	ENSMUSG00000025150	23
Hpgd / Q8VCC1 / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / P15428* / 15-hydroxyprostaglandin dehydrogenase*	ENSMUSG00000031613	23
Hsd17b10 / hydroxysteroid 17-beta dehydrogenase 10 / Q99714*	ENSMUSG00000025260	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR002347	Short-chain dehydrogenase/reductase SDR
IPR020904	Short-chain dehydrogenase/reductase, conserved site
IPR036291	NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008150	biological_process	ND
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0034599	cellular response to oxidative stress	IEA
biological_process	GO:0043011	myeloid dendritic cell differentiation	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005635	nuclear envelope	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dixdc1^{tm1.1(KOMP)Vlcg}/Dixdc1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Dixdc1^{tm1.1(KOMP)Vlcg}/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr