ENSMUSG00000022210


Mus musculus

Features
Gene ID: ENSMUSG00000022210
  
Biological name :Dhrs4
  
Synonyms : Dehydrogenase/reductase SDR family member 4 / Dhrs4 / Q99LB2
  
Possible biological names infered from orthology : dehydrogenase/reductase 4 / dehydrogenase/reductase 4 like 2 / DHRS4L2 / Q6PKH6 / Q9BTZ2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55478758
Gene end: 55490340
  
Corresponding Affymetrix probe sets: 10415176 (MoGene1.0st)   1419382_a_at (Mouse Genome 430 2.0 Array)   1451559_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154006
Ensembl peptide - ENSMUSP00000022821
Ensembl peptide - ENSMUSP00000153847
Ensembl peptide - ENSMUSP00000154666
Ensembl peptide - ENSMUSP00000154474
Ensembl peptide - ENSMUSP00000154481
NCBI entrez gene - 28200     See in Manteia.
MGI - MGI:90169
RefSeq - NM_001037938
RefSeq - NM_030686
RefSeq Peptide - NP_001033027
RefSeq Peptide - NP_109611
swissprot - Q99LB2
swissprot - Q9D2U3
Ensembl - ENSMUSG00000022210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhrs4ENSDARG00000021135Danio rerio
 DHRS4ENSG00000157326Homo sapiens
 Q6PKH6ENSG00000187630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhrs2 / dehydrogenase/reductase 2 / Q13268*ENSMUSG0000002220953
P50171 / H2-Ke6 / H2-K region expressed gene 6 / Q92506* / HSD17B8* / hydroxysteroid 17-beta dehydrogenase 8*ENSMUSG0000007342227
Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1*ENSMUSG0000003082526
Cbr2 / P08074 / Carbonyl reductase [NADPH] 2 ENSMUSG0000002515025
Dcxr / Q91X52 / L-xylulose reductase / Q7Z4W1* / dicarbonyl and L-xylulose reductase*ENSMUSG0000003945025
Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*ENSMUSG0000003164124
Hsd17b10 / hydroxysteroid 17-beta dehydrogenase 10 / Q99714*ENSMUSG0000002526024
Bdh2 / Q8JZV9 / 3-hydroxybutyrate dehydrogenase type 2 / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*ENSMUSG0000002816724
Hpgd / Q8VCC1 / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / P15428* / 15-hydroxyprostaglandin dehydrogenase*ENSMUSG0000003161322


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR029511  Dehydrogenase/reductase SDR member 4-like
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006066 alcohol metabolic process ISO
 biological_processGO:0008202 steroid metabolic process ISO
 biological_processGO:0042180 cellular ketone metabolic process ISO
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0051262 protein tetramerization ISO
 biological_processGO:0055114 oxidation-reduction process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane ISO
 molecular_functionGO:0000253 3-keto sterol reductase activity ISO
 molecular_functionGO:0001758 retinal dehydrogenase activity IDA
 molecular_functionGO:0004090 carbonyl reductase (NADPH) activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
 molecular_functionGO:0018455 alcohol dehydrogenase [NAD(P)+] activity ISO


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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