ENSMUSG00000030825


Mus musculus

Features
Gene ID: ENSMUSG00000030825
  
Biological name :Hsd17b14
  
Synonyms : Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14
  
Possible biological names infered from orthology : Q9BPX1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45554893
Gene end: 45567752
  
Corresponding Affymetrix probe sets: 10553004 (MoGene1.0st)   1429802_at (Mouse Genome 430 2.0 Array)   1447678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103381
Ensembl peptide - ENSMUSP00000147851
Ensembl peptide - ENSMUSP00000147715
NCBI entrez gene - 66065     See in Manteia.
MGI - MGI:1913315
RefSeq - NM_025330
RefSeq - XM_006541070
RefSeq Peptide - NP_079606
swissprot - A0A1B0GS97
swissprot - A0A1B0GRY4
swissprot - E9Q3D4
Ensembl - ENSMUSG00000030825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b14ENSDARG00000054842Danio rerio
 Q9BPX1ENSG00000087076Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P50171 / H2-Ke6 / H2-K region expressed gene 6 / Q92506* / HSD17B8* / hydroxysteroid 17-beta dehydrogenase 8*ENSMUSG0000007342229
Bdh2 / Q8JZV9 / 3-hydroxybutyrate dehydrogenase type 2 / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*ENSMUSG0000002816729
Hsd17b10 / hydroxysteroid 17-beta dehydrogenase 10 / Q99714*ENSMUSG0000002526028
Dhrs2 / dehydrogenase/reductase 2 / Q13268*ENSMUSG0000002220928
Dhrs4 / Q99LB2 / Dehydrogenase/reductase SDR family member 4 / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 4* / dehydrogenase/reductase 4 like 2*ENSMUSG0000002221027
Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*ENSMUSG0000003164127
Hpgd / Q8VCC1 / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / P15428* / 15-hydroxyprostaglandin dehydrogenase*ENSMUSG0000003161325
Cbr2 / P08074 / Carbonyl reductase [NADPH] 2 ENSMUSG0000002515023
Dcxr / Q91X52 / L-xylulose reductase / Q7Z4W1* / dicarbonyl and L-xylulose reductase*ENSMUSG0000003945023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006706 steroid catabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity ISO


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0010166 increased response to stress-induced hyperthermia "greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
Show

Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030825 Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1*  / complex






 

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