ENSMUSG00000031613


Mus musculus

Features
Gene ID: ENSMUSG00000031613
  
Biological name :Hpgd
  
Synonyms : 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / Hpgd / Q8VCC1
  
Possible biological names infered from orthology : 15-hydroxyprostaglandin dehydrogenase / P15428
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B2
Gene start: 56294585
Gene end: 56321043
  
Corresponding Affymetrix probe sets: 10571840 (MoGene1.0st)   1419905_s_at (Mouse Genome 430 2.0 Array)   1419906_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034026
NCBI entrez gene - 15446     See in Manteia.
MGI - MGI:108085
RefSeq - NM_008278
RefSeq Peptide - NP_032304
swissprot - Q8VCC1
Ensembl - ENSMUSG00000031613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpgdENSDARG00000012016Danio rerio
 HPGDENSGALG00000010769Gallus gallus
 HPGDENSG00000164120Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P50171 / H2-Ke6 / H2-K region expressed gene 6 / Q92506* / HSD17B8* / hydroxysteroid 17-beta dehydrogenase 8*ENSMUSG0000007342227
Bdh2 / Q8JZV9 / 3-hydroxybutyrate dehydrogenase type 2 / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*ENSMUSG0000002816727
Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1*ENSMUSG0000003082526
Hsd17b10 / hydroxysteroid 17-beta dehydrogenase 10 / Q99714*ENSMUSG0000002526026
Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*ENSMUSG0000003164125
Dhrs2 / dehydrogenase/reductase 2 / Q13268*ENSMUSG0000002220924
Dhrs4 / Q99LB2 / Dehydrogenase/reductase SDR family member 4 / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 4* / dehydrogenase/reductase 4 like 2*ENSMUSG0000002221023
Cbr2 / P08074 / Carbonyl reductase [NADPH] 2 ENSMUSG0000002515021
Dcxr / Q91X52 / L-xylulose reductase / Q7Z4W1* / dicarbonyl and L-xylulose reductase*ENSMUSG0000003945021


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006693 prostaglandin metabolic process ISS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007567 parturition IEA
 biological_processGO:0030728 ovulation ISS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0097070 ductus arteriosus closure IMP
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004957 prostaglandin E receptor activity IEA
 molecular_functionGO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of Lipoxins (LX)
Biosynthesis of D-series resolvins
Biosynthesis of E-series 18(S)-resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009811 abnormal prostaglandin level "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Hpgdtm1Ljm/Hpgdtm1Ljm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012009 early parturition "the process of labor and delivery in female animals occurs earlier in gestation than expected" [MGI:csmith]
Show

Allelic Composition: Hpgdtm1Ljm/Hpgdtm1Ljm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Hpgdtm1Ljm/Hpgd+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031613 Hpgd / Q8VCC1 / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / P15428* / 15-hydroxyprostaglandin dehydrogenase*  / complex






 

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