ENSG00000087076


Homo sapiens

Features
Gene ID: ENSG00000087076
  
Biological name :HSD17B14
  
Synonyms : HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 48813017
Gene end: 48836678
  
Corresponding Affymetrix probe sets: 219113_x_at (Human Genome U133 Plus 2.0 Array)   224494_x_at (Human Genome U133 Plus 2.0 Array)   224497_x_at (Human Genome U133 Plus 2.0 Array)   228713_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472746
Ensembl peptide - ENSP00000263278
Ensembl peptide - ENSP00000469557
Ensembl peptide - ENSP00000471631
NCBI entrez gene - 51171     See in Manteia.
OMIM - 612832
RefSeq - XM_005258970
RefSeq - NM_016246
RefSeq - XM_005258969
RefSeq Peptide - NP_057330
swissprot - M0R2R3
swissprot - A0A140VJH8
swissprot - Q9BPX1
swissprot - M0QY35
swissprot - M0R147
Ensembl - ENSG00000087076
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b14ENSDARG00000054842Danio rerio
 Hsd17b14ENSMUSG00000030825Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99714 / HSD17B10 / hydroxysteroid 17-beta dehydrogenase 10ENSG0000007250629
Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8ENSG0000020422828
BDH2 / Q9BUT1 / 3-hydroxybutyrate dehydrogenase 2ENSG0000016403927
CBR4 / Q8N4T8 / carbonyl reductase 4ENSG0000014543927
DHRS4 / Q9BTZ2 / dehydrogenase/reductase 4ENSG0000015732627
DHRS2 / Q13268 / dehydrogenase/reductase 2ENSG0000010086726
HPGD / P15428 / 15-hydroxyprostaglandin dehydrogenaseENSG0000016412026
DCXR / Q7Z4W1 / dicarbonyl and L-xylulose reductaseENSG0000016973825
Q6PKH6 / DHRS4L2 / dehydrogenase/reductase 4 like 2ENSG0000018763020


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006703 estrogen biosynthetic process TAS
 biological_processGO:0006706 steroid catabolic process IDA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity IDA


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087076 Q9BPX1 / HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14  / complex






 

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