ENSG00000157326


Homo sapiens

Features
Gene ID: ENSG00000157326
  
Biological name :DHRS4
  
Synonyms : dehydrogenase/reductase 4 / DHRS4 / Q9BTZ2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q11.2
Gene start: 23953586
Gene end: 23969279
  
Corresponding Affymetrix probe sets: 218021_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454099
Ensembl peptide - ENSP00000453367
Ensembl peptide - ENSP00000453983
Ensembl peptide - ENSP00000326219
Ensembl peptide - ENSP00000380264
Ensembl peptide - ENSP00000380265
Ensembl peptide - ENSP00000440508
Ensembl peptide - ENSP00000452645
NCBI entrez gene - 10901     See in Manteia.
OMIM - 611596
RefSeq - XM_006720005
RefSeq - NM_001282987
RefSeq - NM_001282988
RefSeq - NM_001282989
RefSeq - NM_001282990
RefSeq - NM_001282991
RefSeq - NM_021004
RefSeq Peptide - NP_001269920
RefSeq Peptide - NP_066284
RefSeq Peptide - NP_001269917
RefSeq Peptide - NP_001269916
RefSeq Peptide - NP_001269918
RefSeq Peptide - NP_001269919
swissprot - Q9BTZ2
swissprot - H0YNP7
swissprot - F5GWZ1
Ensembl - ENSG00000157326
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhrs4ENSDARG00000021135Danio rerio
 Dhrs4ENSMUSG00000022210Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PKH6 / DHRS4L2 / dehydrogenase/reductase 4 like 2ENSG0000018763074
DHRS2 / Q13268 / dehydrogenase/reductase 2ENSG0000010086753
Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8ENSG0000020422829
DCXR / Q7Z4W1 / dicarbonyl and L-xylulose reductaseENSG0000016973828
Q9BPX1 / HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14ENSG0000008707627
CBR4 / Q8N4T8 / carbonyl reductase 4ENSG0000014543927
Q99714 / HSD17B10 / hydroxysteroid 17-beta dehydrogenase 10ENSG0000007250625
BDH2 / Q9BUT1 / 3-hydroxybutyrate dehydrogenase 2ENSG0000016403924
HPGD / P15428 / 15-hydroxyprostaglandin dehydrogenaseENSG0000016412024


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR029511  Dehydrogenase/reductase SDR member 4-like
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006066 alcohol metabolic process IDA
 biological_processGO:0008202 steroid metabolic process IDA
 biological_processGO:0042180 cellular ketone metabolic process IDA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0055114 oxidation-reduction process TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000253 3-keto sterol reductase activity IDA
 molecular_functionGO:0004090 carbonyl reductase (NADPH) activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
 molecular_functionGO:0018455 alcohol dehydrogenase [NAD(P)+] activity IDA
 molecular_functionGO:0052650 NADP-retinol dehydrogenase activity TAS


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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