ENSG00000204228


Homo sapiens

Features
Gene ID: ENSG00000204228
  
Biological name :HSD17B8
  
Synonyms : HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8 / Q92506
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.32
Gene start: 33204642
Gene end: 33206831
  
Corresponding Affymetrix probe sets: 213540_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363794
NCBI entrez gene - 7923     See in Manteia.
OMIM - 601417
RefSeq - NM_014234
RefSeq Peptide - NP_055049
swissprot - A0A1U9X7U3
swissprot - Q92506
Ensembl - ENSG00000204228
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b8ENSDARG00000001169Danio rerio
 H2-Ke6ENSMUSG00000073422Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBR4 / Q8N4T8 / carbonyl reductase 4ENSG0000014543932
DHRS4 / Q9BTZ2 / dehydrogenase/reductase 4ENSG0000015732631
Q99714 / HSD17B10 / hydroxysteroid 17-beta dehydrogenase 10ENSG0000007250630
Q9BPX1 / HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14ENSG0000008707629
BDH2 / Q9BUT1 / 3-hydroxybutyrate dehydrogenase 2ENSG0000016403928
DCXR / Q7Z4W1 / dicarbonyl and L-xylulose reductaseENSG0000016973828
HPGD / P15428 / 15-hydroxyprostaglandin dehydrogenaseENSG0000016412027
DHRS2 / Q13268 / dehydrogenase/reductase 2ENSG0000010086725
Q6PKH6 / DHRS4L2 / dehydrogenase/reductase 4 like 2ENSG0000018763023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IMP
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006703 estrogen biosynthetic process IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008210 estrogen metabolic process IEA
 biological_processGO:0046949 fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IDA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IMP
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0070404 NADH binding IDA


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145439 CBR4 / Q8N4T8 / carbonyl reductase 4  / complex
 ENSG00000204228 Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8  / complex






 

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