ENSG00000145439


Homo sapiens

Features
Gene ID: ENSG00000145439
  
Biological name :CBR4
  
Synonyms : carbonyl reductase 4 / CBR4 / Q8N4T8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q32.3
Gene start: 168863770
Gene end: 169010275
  
Corresponding Affymetrix probe sets: 1553693_s_at (Human Genome U133 Plus 2.0 Array)   213626_at (Human Genome U133 Plus 2.0 Array)   244052_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425671
Ensembl peptide - ENSP00000423128
Ensembl peptide - ENSP00000427615
Ensembl peptide - ENSP00000424717
Ensembl peptide - ENSP00000303525
Ensembl peptide - ENSP00000421254
NCBI entrez gene - 84869     See in Manteia.
RefSeq - XM_017008783
RefSeq - XM_005263315
RefSeq - XM_005263316
RefSeq - XM_006714391
RefSeq - XM_006714392
RefSeq - XM_011532385
RefSeq - XM_017008782
RefSeq - NM_032783
RefSeq Peptide - NP_116172
swissprot - D6RJF4
swissprot - D6RGF2
swissprot - H0Y962
swissprot - D6RAV8
swissprot - Q8N4T8
Ensembl - ENSG00000145439
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbr4ENSDARG00000009074Danio rerio
 CBR4ENSGALG00000009714Gallus gallus
 Cbr4ENSMUSG00000031641Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8ENSG0000020422835
DHRS4 / Q9BTZ2 / dehydrogenase/reductase 4ENSG0000015732631
Q9BPX1 / HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14ENSG0000008707631
HPGD / P15428 / 15-hydroxyprostaglandin dehydrogenaseENSG0000016412029
DHRS2 / Q13268 / dehydrogenase/reductase 2ENSG0000010086729
Q99714 / HSD17B10 / hydroxysteroid 17-beta dehydrogenase 10ENSG0000007250629
DCXR / Q7Z4W1 / dicarbonyl and L-xylulose reductaseENSG0000016973827
BDH2 / Q9BUT1 / 3-hydroxybutyrate dehydrogenase 2ENSG0000016403926
Q6PKH6 / DHRS4L2 / dehydrogenase/reductase 4 like 2ENSG0000018763024


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IMP
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0046949 fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0051289 protein homotetramerization IPI
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:1990204 oxidoreductase complex IMP
 molecular_functionGO:0003955 NAD(P)H dehydrogenase (quinone) activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008753 NADPH dehydrogenase (quinone) activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IMP
 molecular_functionGO:0048038 quinone binding ISS
 molecular_functionGO:0070402 NADPH binding ISS


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204228 Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8  / complex
 ENSG00000145439 CBR4 / Q8N4T8 / carbonyl reductase 4  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr