ENSMUSG00000029683


Mus musculus

Features
Gene ID: ENSMUSG00000029683
  
Biological name :Lmod2
  
Synonyms : Leiomodin-2 / Lmod2 / Q3UHZ5
  
Possible biological names infered from orthology : Q6P5Q4
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.1
Gene start: 24597762
Gene end: 24605414
  
Corresponding Affymetrix probe sets: 10536711 (MoGene1.0st)   1452345_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031694
NCBI entrez gene - 93677     See in Manteia.
MGI - MGI:2135672
RefSeq - NM_053098
RefSeq Peptide - NP_444328
swissprot - Q3UHZ5
Ensembl - ENSMUSG00000029683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmod2aENSDARG00000045634Danio rerio
 lmod2bENSDARG00000045864Danio rerio
 LMOD2ENSGALG00000008805Gallus gallus
 LMOD2ENSG00000170807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmod1 / leiomodin 1 / P29536*ENSMUSG0000004809640
Lmod3 / E9QA62 / Leiomodin-3 / Q0VAK6*ENSMUSG0000004408636
Tmod2 / Q9JKK7 / tropomodulin 2 / Q9NZR1*ENSMUSG0000003218626
Tmod1 / P49813 / Tropomodulin-1 / P28289*ENSMUSG0000002832826
Tmod3 / Q9JHJ0 / tropomodulin 3 / Q9NYL9*ENSMUSG0000005858724
Tmod4 / Q9JLH8 / tropomodulin 4 / Q9NZQ9*ENSMUSG0000000562823


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030132  Leiomodin-2
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IBA
 biological_processGO:0030041 actin filament polymerization IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0051694 pointed-end actin filament capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IBA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030017 sarcomere ISO
 cellular_componentGO:0031430 M band ISO
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0005523 tropomyosin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0004146 absent M lines "missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmod2Tn(pb-Act-RFP)1.1Zhu/Lmod2Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: FVB/N

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Lmod2tm1(KOMP)Vlcg/Lmod2tm1(KOMP)Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac * CBA

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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