ENSMUSG00000032186


Mus musculus

Features
Gene ID: ENSMUSG00000032186
  
Biological name :Tmod2
  
Synonyms : Q9JKK7 / Tmod2 / tropomodulin 2
  
Possible biological names infered from orthology : Q9NZR1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 75565621
Gene end: 75611325
  
Corresponding Affymetrix probe sets: 10595013 (MoGene1.0st)   1430153_at (Mouse Genome 430 2.0 Array)   1431326_a_at (Mouse Genome 430 2.0 Array)   1435060_at (Mouse Genome 430 2.0 Array)   1437167_at (Mouse Genome 430 2.0 Array)   1439223_at (Mouse Genome 430 2.0 Array)   1451301_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150170
Ensembl peptide - ENSMUSP00000150750
Ensembl peptide - ENSMUSP00000150645
Ensembl peptide - ENSMUSP00000150413
Ensembl peptide - ENSMUSP00000069956
Ensembl peptide - ENSMUSP00000096152
Ensembl peptide - ENSMUSP00000126739
Ensembl peptide - ENSMUSP00000149584
NCBI entrez gene - 50876     See in Manteia.
MGI - MGI:1355335
RefSeq - XM_006511267
RefSeq - XM_017313459
RefSeq - XM_017313460
RefSeq - NM_001038710
RefSeq - NM_016711
RefSeq - XM_006511268
RefSeq Peptide - NP_001033799
RefSeq Peptide - NP_057920
swissprot - Q9JKK7
swissprot - A0A1L1SU70
swissprot - A0A1L1SRR7
swissprot - A0A1L1ST54
Ensembl - ENSMUSG00000032186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmod2ENSDARG00000002571Danio rerio
 TMOD2ENSGALG00000004740Gallus gallus
 TMOD2ENSG00000128872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmod3 / Q9JHJ0 / tropomodulin 3 / Q9NYL9*ENSMUSG0000005858774
Tmod1 / P49813 / Tropomodulin-1 / P28289*ENSMUSG0000002832860
Tmod4 / Q9JLH8 / tropomodulin 4 / Q9NZQ9*ENSMUSG0000000562852
Lmod2 / Q3UHZ5 / Leiomodin-2 / Q6P5Q4*ENSMUSG0000002968340
Lmod1 / leiomodin 1 / P29536*ENSMUSG0000004809636
Lmod3 / E9QA62 / Leiomodin-3 / Q0VAK6*ENSMUSG0000004408635


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030130  Tropomodulin-2
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IBA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0030239 myofibril assembly IBA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0051694 pointed-end actin filament capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IBA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005523 tropomyosin binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Tmod2tm2Hzo/Tmod2tm2Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Tmod2tm2Hzo/Tmod2tm2Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Tmod2tm2Hzo/Tmod2tm2Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmod2tm2Hzo/Tmod2tm2Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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