ENSMUSG00000058587


Mus musculus

Features
Gene ID: ENSMUSG00000058587
  
Biological name :Tmod3
  
Synonyms : Q9JHJ0 / Tmod3 / tropomodulin 3
  
Possible biological names infered from orthology : Q9NYL9
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 75497707
Gene end: 75559657
  
Corresponding Affymetrix probe sets: 10595000 (MoGene1.0st)   1423088_at (Mouse Genome 430 2.0 Array)   1423089_at (Mouse Genome 430 2.0 Array)   1438556_a_at (Mouse Genome 430 2.0 Array)   1439626_at (Mouse Genome 430 2.0 Array)   1455708_at (Mouse Genome 430 2.0 Array)   1456913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072087
Ensembl peptide - ENSMUSP00000149300
Ensembl peptide - ENSMUSP00000148851
NCBI entrez gene - 50875     See in Manteia.
MGI - MGI:1355315
RefSeq - NM_016963
RefSeq - XM_017313458
RefSeq Peptide - NP_058659
swissprot - A0A1L1SR42
swissprot - Q9JHJ0
swissprot - A0A1L1SQ12
Ensembl - ENSMUSG00000058587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmod2ENSDARG00000002571Danio rerio
 TMOD3ENSGALG00000004710Gallus gallus
 TMOD3ENSG00000138594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmod2 / Q9JKK7 / tropomodulin 2 / Q9NZR1*ENSMUSG0000003218673
Tmod1 / P49813 / Tropomodulin-1 / P28289*ENSMUSG0000002832861
Tmod4 / Q9JLH8 / tropomodulin 4 / Q9NZQ9*ENSMUSG0000000562855
Lmod2 / Q3UHZ5 / Leiomodin-2 / Q6P5Q4*ENSMUSG0000002968338
Lmod1 / leiomodin 1 / P29536*ENSMUSG0000004809635
Lmod3 / E9QA62 / Leiomodin-3 / Q0VAK6*ENSMUSG0000004408634


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030133  Tropomodulin-3
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IBA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030239 myofibril assembly IBA
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0051271 negative regulation of cellular component movement ISO
 biological_processGO:0051694 pointed-end actin filament capping IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1901992 positive regulation of mitotic cell cycle phase transition IMP
 cellular_componentGO:0001726 ruffle ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0031941 filamentous actin ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005523 tropomyosin binding IEA
 molecular_functionGO:0051011 microtubule minus-end binding ISO
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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