ENSMUSG00000044086


Mus musculus

Features
Gene ID: ENSMUSG00000044086
  
Biological name :Lmod3
  
Synonyms : E9QA62 / Leiomodin-3 / Lmod3
  
Possible biological names infered from orthology : Q0VAK6
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 97238534
Gene end: 97252759
  
Corresponding Affymetrix probe sets: 10546624 (MoGene1.0st)   1439658_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093315
NCBI entrez gene - 320502     See in Manteia.
MGI - MGI:2444169
RefSeq - XM_006506271
RefSeq - NM_001081157
RefSeq - XM_006506270
RefSeq Peptide - NP_001074626
swissprot - E9QA62
Ensembl - ENSMUSG00000044086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmod3ENSDARG00000062662Danio rerio
 LMOD3ENSGALG00000018946Gallus gallus
 LMOD3ENSG00000163380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmod2 / Q3UHZ5 / Leiomodin-2 / Q6P5Q4*ENSMUSG0000002968335
Lmod1 / leiomodin 1 / P29536*ENSMUSG0000004809634
Tmod2 / Q9JKK7 / tropomodulin 2 / Q9NZR1*ENSMUSG0000003218622
Tmod1 / P49813 / Tropomodulin-1 / P28289*ENSMUSG0000002832822
Tmod3 / Q9JHJ0 / tropomodulin 3 / Q9NYL9*ENSMUSG0000005858721
Tmod4 / Q9JLH8 / tropomodulin 4 / Q9NZQ9*ENSMUSG0000000562820


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030131  Leiomodin-3
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IBA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0030239 myofibril assembly IBA
 biological_processGO:0030240 skeletal muscle thin filament assembly IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IEA
 biological_processGO:0051694 pointed-end actin filament capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IEA
 cellular_componentGO:0031430 M band ISO
 cellular_componentGO:0031672 A band IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005523 tropomyosin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cd276tm1Lpc/Cd276tm1Lpc
Genetic Background: D1J.129-Cd276tm1Lpc

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Lmod3Tn(pb-Act-RFP)1.1Zhu/Lmod3Tn(pb-Act-RFP)1.1Zhu
Genetic Background: involves: C57BL/6J

 MP:0010240 decreased skeletal muscle size "less than average dimensions of one or more of the muscles of the skeleton" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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