ENSMUSG00000028328


Mus musculus

Features
Gene ID: ENSMUSG00000028328
  
Biological name :Tmod1
  
Synonyms : P49813 / Tmod1 / Tropomodulin-1
  
Possible biological names infered from orthology : P28289
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 46038935
Gene end: 46116032
  
Corresponding Affymetrix probe sets: 10504692 (MoGene1.0st)   1422754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103402
Ensembl peptide - ENSMUSP00000134075
NCBI entrez gene - 21916     See in Manteia.
MGI - MGI:98775
RefSeq - XM_006537773
RefSeq - NM_021883
RefSeq - XM_006537772
RefSeq Peptide - NP_068683
swissprot - P49813
swissprot - G3UYG4
Ensembl - ENSMUSG00000028328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmod1ENSDARG00000078318Danio rerio
 TMOD1ENSGALG00000002125Gallus gallus
 TMOD1ENSG00000136842Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmod3 / Q9JHJ0 / tropomodulin 3 / Q9NYL9*ENSMUSG0000005858760
Tmod2 / Q9JKK7 / tropomodulin 2 / Q9NZR1*ENSMUSG0000003218658
Tmod4 / Q9JLH8 / tropomodulin 4 / Q9NZQ9*ENSMUSG0000000562855
Lmod2 / Q3UHZ5 / Leiomodin-2 / Q6P5Q4*ENSMUSG0000002968340
Lmod1 / leiomodin 1 / P29536*ENSMUSG0000004809636
Lmod3 / E9QA62 / Leiomodin-3 / Q0VAK6*ENSMUSG0000004408635


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030135  Tropomodulin-1
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0051694 pointed-end actin filament capping IEA
 biological_processGO:0070307 lens fiber cell development IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005865 striated muscle thin filament IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005523 tropomyosin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001627 abnormal cardiac output "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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