ENSMUSG00000031314


Mus musculus

Features
Gene ID: ENSMUSG00000031314
  
Biological name :Taf1
  
Synonyms : Q80UV9 / Taf1 / TATA-box binding protein associated factor 1
  
Possible biological names infered from orthology : P21675 / Q8IZX4 / TAF1L / TATA-box binding protein associated factor 1 like
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101532734
Gene end: 101601789
  
Corresponding Affymetrix probe sets: 10601192 (MoGene1.0st)   1447417_at (Mouse Genome 430 2.0 Array)   1455513_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138159
Ensembl peptide - ENSMUSP00000098895
Ensembl peptide - ENSMUSP00000112772
Ensembl peptide - ENSMUSP00000114765
NCBI entrez gene - 270627     See in Manteia.
MGI - MGI:1336878
RefSeq - XM_017318518
RefSeq - XM_017318513
RefSeq - XM_017318514
RefSeq - XM_017318515
RefSeq - XM_017318516
RefSeq - XM_017318517
RefSeq - NM_001290729
RefSeq - XM_006528050
RefSeq - XM_006528051
RefSeq - XM_006528052
RefSeq - XM_006528053
RefSeq - XM_017318512
RefSeq Peptide - NP_001277658
swissprot - D3YZK4
swissprot - B1Q2W7
swissprot - Q80UV9
swissprot - S4R1B9
Ensembl - ENSMUSG00000031314
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf1ENSDARG00000035330Danio rerio
 ENSGALG00000005464Gallus gallus
 TAF1ENSG00000147133Homo sapiens
 TAF1LENSG00000122728Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zmynd8 / zinc finger, MYND-type containing 8 / Q9ULU4*ENSMUSG0000003967111
Q8R5C8 / Zmynd11 / zinc finger, MYND domain containing 11 / Q15326* / zinc finger MYND-type containing 11*ENSMUSG000000211564


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR009067  TAFII-230 TBP-binding
 IPR011177  Transcription initiation factor TFIID subunit 1, animal
 IPR018359  Bromodomain, conserved site
 IPR022591  Transcription initiation factor TFIID subunit 1, domain of unknown function
 IPR036427  Bromodomain-like superfamily
 IPR036741  TAFII-230 TBP-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016573 histone acetylation IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0030901 midbrain development ISO
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0036369 transcription factor catabolic process ISO
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0071318 cellular response to ATP ISO
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
 biological_processGO:1905524 negative regulation of protein autoubiquitination ISO
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process ISO
 biological_processGO:2000825 positive regulation of androgen receptor activity ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0071339 MLL1 complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA
 molecular_functionGO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly IBA
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0017025 TBP-class protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0061628 H3K27me3 modified histone binding ISO
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity ISO
 molecular_functionGO:0070577 lysine-acetylated histone binding ISO


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction






 

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