ENSMUSG00000031965


Mus musculus

Features
Gene ID: ENSMUSG00000031965
  
Biological name :Tbx20
  
Synonyms : Q9ES03 / T-box transcription factor TBX20 / Tbx20
  
Possible biological names infered from orthology : Q9UMR3 / T-box 20
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 24718138
Gene end: 24774303
  
Corresponding Affymetrix probe sets: 10591853 (MoGene1.0st)   1422219_a_at (Mouse Genome 430 2.0 Array)   1425158_at (Mouse Genome 430 2.0 Array)   1453351_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052591
Ensembl peptide - ENSMUSP00000126318
Ensembl peptide - ENSMUSP00000149186
NCBI entrez gene - 57246     See in Manteia.
MGI - MGI:1888496
RefSeq - NM_001205085
RefSeq - NM_020496
RefSeq - NM_194263
RefSeq Peptide - NP_001192014
RefSeq Peptide - NP_065242
RefSeq Peptide - NP_919239
swissprot - Q9ES03
swissprot - A0A1L1SQU0
Ensembl - ENSMUSG00000031965
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx20ENSDARG00000005150Danio rerio
 TBX20ENSGALG00000032097Gallus gallus
 TBX20ENSG00000164532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbx15 / O70306 / T-box transcription factor TBX15 / Q96SF7* / T-box 15*ENSMUSG0000002786840
Tbx18 / T-box 18 / O95935*ENSMUSG0000003241939
Tbx22 / Q8K402 / T-box 22 / Q9Y458*ENSMUSG0000003124136
Tbx2 / Q60707 / T-box transcription factor TBX2 / Q13207* / T-box 2*ENSMUSG0000000009334
Tbx3 / P70324 / T-box 3 / O15119*ENSMUSG0000001860433
Tbx1 / T-box 1 / O43435*ENSMUSG0000000909733
Tbx5 / P70326 / T-box 5 / Q99593*ENSMUSG0000001826331
Tbx10 / Q810F8 / T-box transcription factor TBX10 / O75333* / T-box 10*ENSMUSG0000003747730
Tbx4 / P70325 / T-box 4 / P57082*ENSMUSG0000000009430
Tbx6 / P70327 / T-box transcription factor TBX6 / O95947* / T-box 6*ENSMUSG0000003069927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003148 outflow tract septum morphogenesis ISO
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003175 tricuspid valve development IMP
 biological_processGO:0003176 aortic valve development IMP
 biological_processGO:0003180 aortic valve morphogenesis ISO
 biological_processGO:0003193 pulmonary valve formation IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003207 cardiac chamber formation IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003272 endocardial cushion formation IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0003344 pericardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition NAS
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly IDA
 biological_processGO:0021524 visceral motor neuron differentiation IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035922 foramen ovale closure ISO
 biological_processGO:0036306 embryonic heart tube elongation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060413 atrial septum morphogenesis ISO
 biological_processGO:0060577 pulmonary vein morphogenesis ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,spkw2C3H/HeJ/spkw2C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph,Tbx20tm1.1Rph/Tbx20tm1.1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,spkw2C3H/HeJ/spkw2C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Tbx20tm1.2Rph/Tbx20tm1.2Rph
Genetic Background: B6.Cg-Tbx20tm1.2Rph

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph,Tbx20tm1.1Rph/Tbx20tm1.1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nkx2-5tm3Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: C57BL/6

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tbx20tm1Akis/Tbx20tm1Akis
Genetic Background: involves: 129S1/SvImJ * NMRI

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
Show

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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