ENSMUSG00000000094


Mus musculus

Features
Gene ID: ENSMUSG00000000094
  
Biological name :Tbx4
  
Synonyms : P70325 / T-box 4 / Tbx4
  
Possible biological names infered from orthology : P57082
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 85886422
Gene end: 85916097
  
Corresponding Affymetrix probe sets: 10379944 (MoGene1.0st)   1426321_at (Mouse Genome 430 2.0 Array)   1456033_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000096
Ensembl peptide - ENSMUSP00000103680
Ensembl peptide - ENSMUSP00000103682
NCBI entrez gene - 21387     See in Manteia.
MGI - MGI:102556
RefSeq - XM_006532781
RefSeq - NM_011536
RefSeq - NM_172798
RefSeq - XM_006532779
RefSeq - XM_006532780
RefSeq Peptide - NP_035666
RefSeq Peptide - NP_766386
swissprot - Q8BSY3
swissprot - P70325
Ensembl - ENSMUSG00000000094
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx4ENSDARG00000030058Danio rerio
 TBX4ENSGALG00000005285Gallus gallus
 TBX4ENSG00000121075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbx5 / P70326 / T-box 5 / Q99593*ENSMUSG0000001826353
Tbx2 / Q60707 / T-box transcription factor TBX2 / Q13207* / T-box 2*ENSMUSG0000000009330
Tbx3 / P70324 / T-box 3 / O15119*ENSMUSG0000001860430
Tbx15 / O70306 / T-box transcription factor TBX15 / Q96SF7* / T-box 15*ENSMUSG0000002786826
Tbx1 / T-box 1 / O43435*ENSMUSG0000000909726
Tbx18 / T-box 18 / O95935*ENSMUSG0000003241925
Tbx10 / Q810F8 / T-box transcription factor TBX10 / O75333* / T-box 10*ENSMUSG0000003747725
Tbx20 / Q9ES03 / T-box transcription factor TBX20 / Q9UMR3* / T-box 20*ENSMUSG0000003196524
Tbx6 / P70327 / T-box transcription factor TBX6 / O95947* / T-box 6*ENSMUSG0000003069923
Tbx22 / Q8K402 / T-box 22 / Q9Y458*ENSMUSG0000003124122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0035108 limb morphogenesis ISS
 biological_processGO:0048705 skeletal system morphogenesis ISS
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre/ERT2)1Mlgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm3Jzh/Pkd1tm3Jzh,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Tbx4tm1(cre)Tmj/Tbx4tm1(cre)Tmj
Genetic Background: Not Specified

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Tbx4tm1(cre)Tmj/Tbx4+
Genetic Background: involves: 129

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003230 abnormal umbilical artery "malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0003891 increased allantois apoptosis "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004349 absent femur "missing the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004558 delayed allantois development "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tbx4tm1.1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre/ERT2)1Mlgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008919 fused tarsal bones "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pth2tm1Vlcg/Pth2tm1Vlcg,Tg(CAG-LacZ,-Pth2)1Tbu/0,Tg(Prm-cre)58Og/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

 MP:0009656 delayed chorioallantoic fusion "late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0012134 absent umbilical cord "absence of or failure to form the connective stalk between the fetus and the placenta" [MGI:anna]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013169 small hindlimb buds "reduced size of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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