Manteia - Molecule gene

ENSMUSG00000032419

Mus musculus

Features

Gene ID:	ENSMUSG00000032419

Biological name :	Tbx18

Synonyms :	T-box 18 / Tbx18

Possible biological names infered from orthology :	O95935

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	E3.1
Gene start:	87702800
Gene end:	87731260

Corresponding Affymetrix probe sets:	10595560 (MoGene1.0st) 1429974_at (Mouse Genome 430 2.0 Array) 1449871_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000034991 NCBI entrez gene - 76365 See in Manteia. MGI - MGI:1923615 RefSeq - NM_023814 RefSeq Peptide - NP_076303 swissprot - G3X919 Ensembl - ENSMUSG00000032419

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tbx18	ENSDARG00000036930	Danio rerio
TBX18	ENSGALG00000032789	Gallus gallus
TBX18	ENSG00000112837	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tbx15 / O70306 / T-box transcription factor TBX15 / Q96SF7* / T-box 15*	ENSMUSG00000027868	56
Tbx22 / Q8K402 / T-box 22 / Q9Y458*	ENSMUSG00000031241	36
Tbx20 / Q9ES03 / T-box transcription factor TBX20 / Q9UMR3* / T-box 20*	ENSMUSG00000031965	29
Tbx1 / T-box 1 / O43435*	ENSMUSG00000009097	25
Tbx3 / P70324 / T-box 3 / O15119*	ENSMUSG00000018604	25
Tbx2 / Q60707 / T-box transcription factor TBX2 / Q13207* / T-box 2*	ENSMUSG00000000093	25
Tbx10 / Q810F8 / T-box transcription factor TBX10 / O75333* / T-box 10*	ENSMUSG00000037477	23
Tbx4 / P70325 / T-box 4 / P57082*	ENSMUSG00000000094	23
Tbx5 / P70326 / T-box 5 / Q99593*	ENSMUSG00000018263	22
Tbx6 / P70327 / T-box transcription factor TBX6 / O95947* / T-box 6*	ENSMUSG00000030699	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001699	Transcription factor, T-box
IPR008967	p53-like transcription factor, DNA-binding
IPR018186	Transcription factor, T-box, conserved site
IPR036960	T-box superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0072001	renal system development	IEA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cyld^tm1Ref/Cyld⁺ Genetic Background: B6.129-Cyld^tm1Ref
MP:0000288	abnormal pericardium morphology	"malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0000534	abnormal ureter morphology	"anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Magel2^tm1.1Mus/Magel2⁺ Genetic Background: B6.129S2-Magel2^tm1.1Mus Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0000963	fused dorsal root ganglia	"loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0001077	abnormal spinal nerve morphology	"any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Itgb1^tm14.1Ref/Itgb1^tm14.1Ref Genetic Background: Not Specified Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Itgb1^tm14.1Ref/Itgb1^tm14.1Ref Genetic Background: Not Specified Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺,Omp^tm4(cre)Mom/Omp⁺ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itgb1^tm14.1Ref/Itgb1^tm14.1Ref Genetic Background: Not Specified
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt1^tm2.1Fwa/Sirt1^tm2.1Fwa Genetic Background: FVB.129S6-Sirt1^tm2.1Fwa
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sirt1^tm2.1Fwa/Sirt1^tm2.1Fwa Genetic Background: FVB.129S6-Sirt1^tm2.1Fwa
MP:0002725	abnormal vein morphology	"malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cyld^tm1Ref/Cyld⁺ Genetic Background: B6.129-Cyld^tm1Ref
MP:0002740	heart hypoplasia	"decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0002925	abnormal cardiovascular development	"aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0003057	abnormal epicardium morphology	"anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ache^tm1.1Pata/Ache^tm1.1Pata Genetic Background: involves: 129X1/SvJ Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0003228	abnormal sinus venosus	"malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0004056	abnormal myocardial compact layer morphology	"malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004134	abnormal chest morphology	"malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0004682	small intervertebral disk	"reduced size of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004683	absent intervertebral disk	"absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004786	abnormal common cardinal vein morphology	"any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cyld^tm1Ref/Cyld⁺ Genetic Background: B6.129-Cyld^tm1Ref
MP:0005223	abnormal anterior-posterior polarity of the somites	"anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Itgb1^tm14.1Ref/Itgb1^tm14.1Ref Genetic Background: Not Specified
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Tagln^tm1Liw/Tagln⁺,Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0010556	thin ventricle myocardium compact layer	"reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0010728	fusion of atlas and occipital bones	"union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Scn1a^tm1.1Kzy/Scn1a⁺ Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Cul1^tmTye/Cul1^tmTye Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tbx18^tm1.1Akis/Tbx18^tm1.1Akis Genetic Background: involves: 129S1/SvImJ * NMRI Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0011395	decreased fetal cardiomyocyte proliferation	"reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]	Show Allelic Composition: Hprt^{tm4(CAG-Tbx18,-Venus)Akis}/Y,Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Tbx18^tm4(cre)Akis/Tbx18⁺ Genetic Background:* involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
MP:0011426	abnormal ureter smooth muscle morphology	"any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna]	Show Allelic Composition: Magel2^tm1.1Mus/Magel2⁺ Genetic Background: B6.129S2-Magel2^tm1.1Mus
MP:0012496	abnormal pleuropericardial membrane morphology	"any structural anomaly of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity" [MGI:csmith, UBERON:0006278]	Show Allelic Composition: Ins2^Akita/Ins2^Akita,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: C.Cg-Ins2^Akita Itga1^tm1Gdnr

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr