ENSMUSG00000032648


Mus musculus

Features
Gene ID: ENSMUSG00000032648
  
Biological name :Pygm
  
Synonyms : Glycogen phosphorylase, muscle form / Pygm / Q9WUB3
  
Possible biological names infered from orthology : glycogen phosphorylase, muscle associated / P11217
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6384399
Gene end: 6398459
  
Corresponding Affymetrix probe sets: 10460947 (MoGene1.0st)   1448602_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109111
Ensembl peptide - ENSMUSP00000047564
NCBI entrez gene - 19309     See in Manteia.
MGI - MGI:97830
RefSeq - NM_011224
RefSeq Peptide - NP_035354
swissprot - E9PUM3
swissprot - Q9WUB3
Ensembl - ENSMUSG00000032648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pygmaENSDARG00000055518Danio rerio
 pygmbENSDARG00000013317Danio rerio
 PYGMENSG00000068976Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pygb / Q8CI94 / Glycogen phosphorylase, brain form / P11216* / glycogen phosphorylase B*ENSMUSG0000003305984
Pygl / Q9ET01 / Glycogen phosphorylase, liver form / P06737* / glycogen phosphorylase L*ENSMUSG0000002106979


Protein motifs (from Interpro)
Interpro ID Name
 IPR000811  Glycosyl transferase, family 35
 IPR011833  Glycogen/starch/alpha-glucan phosphorylase
 IPR035090  Phosphorylase pyridoxal-phosphate attachment site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005980 glycogen catabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030018 Z disc ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004645 phosphorylase activity IEA
 molecular_functionGO:0008184 glycogen phosphorylase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0102250 linear malto-oligosaccharide phosphorylase activity IEA
 molecular_functionGO:0102499 SHG alpha-glucan phosphorylase activity IEA


Pathways (from Reactome)
Pathway description
Glycogen breakdown (glycogenolysis)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006034 myoglobinuria "presence of myoglobin in the urine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020280 increased creatine kinase level "increased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [GOC:NV, MP:0010089]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction
 ENSMUSG00000025537 Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*  / reaction
 ENSMUSG00000032648 Pygm / Q9WUB3 / Glycogen phosphorylase, muscle form / P11217* / glycogen phosphorylase, muscle associated*  / complex
 ENSMUSG00000034055 Phka1 / P18826 / Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform / P46020* / phosphorylase kinase regulatory subunit alpha 1*  / reaction
 ENSMUSG00000036879 Phkb / Q7TSH2 / Phosphorylase b kinase regulatory subunit beta / Q93100* / phosphorylase kinase regulatory subunit beta*  / reaction






 

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