ENSMUSG00000049265


Mus musculus

Features
Gene ID: ENSMUSG00000049265
  
Biological name :Kcnk3
  
Synonyms : Kcnk3 / O35111 / Potassium channel subfamily K member 3
  
Possible biological names infered from orthology : O14649 / potassium two pore domain channel subfamily K member 3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30588170
Gene end: 30625271
  
Corresponding Affymetrix probe sets: 10520506 (MoGene1.0st)   1425341_at (Mouse Genome 430 2.0 Array)   1425342_a_at (Mouse Genome 430 2.0 Array)   1426058_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098987
NCBI entrez gene - 16527     See in Manteia.
MGI - MGI:1100509
RefSeq - NM_010608
RefSeq Peptide - NP_034738
swissprot - O35111
Ensembl - ENSMUSG00000049265
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk3aENSDARG00000043466Danio rerio
 kcnk3bENSDARG00000052898Danio rerio
 KCNK3ENSGALG00000025971Gallus gallus
 KCNK3ENSG00000171303Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSMUSG0000003676051
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*ENSMUSG0000003523845
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*ENSMUSG0000003385423
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*ENSMUSG0000002338721
Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*ENSMUSG0000002495720
Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*ENSMUSG0000003762420
Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*ENSMUSG0000002324320
Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*ENSMUSG0000003399820
Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*ENSMUSG0000004641017
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*ENSMUSG0000002493615


Protein motifs (from Interpro)
Interpro ID Name
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005406  Potassium channel subfamily K member 3
 IPR013099  Potassium channel domain
 IPR022341  Insulin-like growth factor I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0090102 cochlea development IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005252 open rectifier potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0022841 potassium ion leak channel activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
TWIK-releated acid-sensitive K+ channel (TASK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Dkk3tm1Cni/Dkk3tm1Cni,Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm1(cre)Rpa/Drd1+,Gad1tm1Rpa/Gad1tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049265 Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*  / complex
 ENSMUSG00000036760 Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*  / complex






 

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