Manteia - Molecule gene

ENSMUSG00000023243

Mus musculus

Features

Gene ID:	ENSMUSG00000023243

Biological name :	Kcnk5

Synonyms :	Kcnk5 / potassium two pore domain channel subfamily K member 5

Possible biological names infered from orthology :	O95279

Species:	Mus musculus

Chr. number:	14
Strand:	-1
Band:	A3
Gene start:	20140057
Gene end:	20181809

Corresponding Affymetrix probe sets:	10417798 (MoGene1.0st) 1421852_at (Mouse Genome 430 2.0 Array) 1450398_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000024011 NCBI entrez gene - 16529 See in Manteia. MGI - MGI:1336175 RefSeq - NM_021542 RefSeq Peptide - NP_067517 swissprot - Q9JK62 Ensembl - ENSMUSG00000023243

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kcnk5a	ENSDARG00000023587	Danio rerio
KCNK5	ENSGALG00000034077	Gallus gallus
KCNK5	ENSG00000164626	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*	ENSMUSG00000033854	21
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*	ENSMUSG00000023387	20
Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*	ENSMUSG00000024957	20
Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*	ENSMUSG00000037624	18
Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*	ENSMUSG00000049265	17
Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*	ENSMUSG00000046410	16
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*	ENSMUSG00000035238	16
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*	ENSMUSG00000036760	16
Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*	ENSMUSG00000033998	15
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*	ENSMUSG00000024936	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR003092	Two pore domain potassium channel, TASK family
IPR003280	Two pore domain potassium channel
IPR013099	Potassium channel domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0030322	stabilization of membrane potential	IBA
biological_process	GO:0071804	cellular potassium ion transport	IDA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005249	voltage-gated potassium channel activity	IDA
molecular_function	GO:0005267	potassium channel activity	IEA
molecular_function	GO:0022841	potassium ion leak channel activity	IBA

Pathways (from Reactome)

Pathway description

Phase 4 - resting membrane potential

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Htt^tm2Detl/Htt⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001943	abnormal respiration	"anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cryaa^tm1Ady/Cryaa⁺ Genetic Background: involves: 129
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Cryaa^tm1Ady/Cryaa⁺ Genetic Background: involves: 129
MP:0005556	abnormal kidney clearance	"altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Htt^tm2Detl/Htt⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006316	increased urine sodium level	"higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm2Detl/Htt⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Htt^tm2Detl/Htt⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Kcnk5^{Gt(pGT1.8TM)1Gray}/Kcnk5^{Gt(pGT1.8TM)1Gray} Genetic Background: B6.129P2-Kcnk5^{Gt(pGT1.8TM)1Gray}
MP:0011406	abnormal retrotrapezoid nucleus morphology	"any structural anomaly in the loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain" [MGI:smb, PMID:21900566]	Show Allelic Composition: Cryaa^tm1Ady/Cryaa⁺ Genetic Background: involves: 129
MP:0011459	increased urine chloride ion level	"abnormally large amounts of chloride ion in the urine" [MGI:csmith]	Show Allelic Composition: Kcnk5^{Gt(pGT1.8TM)1Gray}/Kcnk5^{Gt(pGT1.8TM)1Gray} Genetic Background: B6.129P2-Kcnk5^{Gt(pGT1.8TM)1Gray}

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023243	Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr