ENSMUSG00000046410


Mus musculus

Features
Gene ID: ENSMUSG00000046410
  
Biological name :Kcnk6
  
Synonyms : Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6
  
Possible biological names infered from orthology : potassium two pore domain channel subfamily K member 6 / Q9Y257
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 29221926
Gene end: 29232515
  
Corresponding Affymetrix probe sets: 10561702 (MoGene1.0st)   1435342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082975
NCBI entrez gene - 52150     See in Manteia.
MGI - MGI:1891291
RefSeq - NM_001033525
RefSeq Peptide - NP_001028697
swissprot - Q3TBV4
Ensembl - ENSMUSG00000046410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk6ENSDARG00000007383Danio rerio
 KCNK6ENSG00000099337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*ENSMUSG0000003399841
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*ENSMUSG0000002493629
Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*ENSMUSG0000002495728
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*ENSMUSG0000002338728
Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*ENSMUSG0000003762425
Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*ENSMUSG0000002324325
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*ENSMUSG0000003523824
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*ENSMUSG0000003385423
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSMUSG0000003676023
Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*ENSMUSG0000004926522


Protein motifs (from Interpro)
Interpro ID Name
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005408  Two pore domain potassium channel, TWIK family
 IPR005409  Two pore domain potassium channel, TWIK-2
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0060075 regulation of resting membrane potential IMP
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0022841 potassium ion leak channel activity IBA


Pathways (from Reactome)
Pathway description
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004878 increased systemic vascular resistance "increase in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046410 Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*  / complex






 

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