ENSMUSG00000037624


Mus musculus

Features
Gene ID: ENSMUSG00000037624
  
Biological name :Kcnk2
  
Synonyms : Kcnk2 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / P97438
  
Possible biological names infered from orthology : O95069 / potassium two pore domain channel subfamily K member 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 189207930
Gene end: 189402273
  
Corresponding Affymetrix probe sets: 10360972 (MoGene1.0st)   1449158_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141891
Ensembl peptide - ENSMUSP00000141849
Ensembl peptide - ENSMUSP00000142026
Ensembl peptide - ENSMUSP00000142176
Ensembl peptide - ENSMUSP00000078416
Ensembl peptide - ENSMUSP00000106545
Ensembl peptide - ENSMUSP00000136513
NCBI entrez gene - 16526     See in Manteia.
MGI - MGI:109366
RefSeq - XM_017318154
RefSeq - NM_001159850
RefSeq - NM_001281847
RefSeq - NM_001281848
RefSeq - NM_001357119
RefSeq - NM_010607
RefSeq - XM_006497121
RefSeq - XM_006497122
RefSeq Peptide - NP_001153322
RefSeq Peptide - NP_001268776
RefSeq Peptide - NP_001268777
RefSeq Peptide - NP_001344048
RefSeq Peptide - NP_034737
swissprot - Q6P6P9
swissprot - A0A0A6YXK1
swissprot - P97438
swissprot - A0A0R4J279
swissprot - A0A0A6YXX0
Ensembl - ENSMUSG00000037624
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk2aENSDARG00000055123Danio rerio
 kcnk2bENSDARG00000007151Danio rerio
 KCNK2ENSGALG00000009687Gallus gallus
 KCNK2ENSG00000082482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*ENSMUSG0000003385459
Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*ENSMUSG0000002495735
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*ENSMUSG0000002338724
Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*ENSMUSG0000002324321
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*ENSMUSG0000003523821
Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*ENSMUSG0000003399820
Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*ENSMUSG0000004641019
Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*ENSMUSG0000004926519
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSMUSG0000003676019
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*ENSMUSG0000002493617


Protein motifs (from Interpro)
Interpro ID Name
 IPR003280  Two pore domain potassium channel
 IPR003976  Two pore domain potassium channel, TREK
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003231 cardiac ventricle development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007613 memory IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030322 stabilization of membrane potential TAS
 biological_processGO:0042391 regulation of membrane potential IGI
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1900039 positive regulation of cellular response to hypoxia IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044305 calyx of Held IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015271 outward rectifier potassium channel activity IBA
 molecular_functionGO:0022841 potassium ion leak channel activity ISS


Pathways (from Reactome)
Pathway description
TWIK related potassium channel (TREK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003075 response to CNS ischemic injury 
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024957 Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*  / complex
 ENSMUSG00000037624 Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*  / complex
 ENSMUSG00000033854 Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr