ENSG00000082482


Homo sapiens

Features
Gene ID: ENSG00000082482
  
Biological name :KCNK2
  
Synonyms : KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q41
Gene start: 215005775
Gene end: 215237093
  
Corresponding Affymetrix probe sets: 210261_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419633
Ensembl peptide - ENSP00000418706
Ensembl peptide - ENSP00000420203
Ensembl peptide - ENSP00000420569
Ensembl peptide - ENSP00000420499
Ensembl peptide - ENSP00000375764
Ensembl peptide - ENSP00000375765
Ensembl peptide - ENSP00000394033
Ensembl peptide - ENSP00000413460
NCBI entrez gene - 3776     See in Manteia.
OMIM - 603219
RefSeq - XM_017001249
RefSeq - NM_001017424
RefSeq - NM_001017425
RefSeq - NM_014217
RefSeq - XM_011509522
RefSeq - XM_011509523
RefSeq - XM_011509524
RefSeq - XM_017001248
RefSeq Peptide - NP_001017425
RefSeq Peptide - NP_055032
RefSeq Peptide - NP_001017424
swissprot - Q6ZW95
swissprot - C9JXY2
swissprot - C9JDK1
swissprot - F8WDE6
swissprot - U3N6F0
swissprot - U3N834
swissprot - B4DGU6
swissprot - O95069
Ensembl - ENSG00000082482
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk2aENSDARG00000055123Danio rerio
 kcnk2bENSDARG00000007151Danio rerio
 KCNK2ENSGALG00000009687Gallus gallus
 Kcnk2ENSMUSG00000037624Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10ENSG0000010043360
KCNK4 / Q9NYG8 / potassium two pore domain channel subfamily K member 4ENSG0000018245035
KCNK17 / Q96T54 / potassium two pore domain channel subfamily K member 17ENSG0000012478023
KCNK5 / O95279 / potassium two pore domain channel subfamily K member 5ENSG0000016462622
KCNK16 / Q96T55 / potassium two pore domain channel subfamily K member 16ENSG0000009598122
KCNK3 / O14649 / potassium two pore domain channel subfamily K member 3ENSG0000017130320
KCNK15 / Q9H427 / potassium two pore domain channel subfamily K member 15ENSG0000012424920
KCNK1 / O00180 / potassium two pore domain channel subfamily K member 1ENSG0000013575020
KCNK9 / Q9NPC2 / potassium two pore domain channel subfamily K member 9ENSG0000016942719
KCNK6 / Q9Y257 / potassium two pore domain channel subfamily K member 6ENSG0000009933719
KCNK7 / Q9Y2U2 / potassium two pore domain channel subfamily K member 7ENSG0000017333818


Protein motifs (from Interpro)
Interpro ID Name
 IPR003280  Two pore domain potassium channel
 IPR003976  Two pore domain potassium channel, TREK
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003231 cardiac ventricle development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1900039 positive regulation of cellular response to hypoxia IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044305 calyx of Held IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA
 molecular_functionGO:0022841 potassium ion leak channel activity IEA


Pathways (from Reactome)
Pathway description
TWIK related potassium channel (TREK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082482 KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2  / complex
 ENSG00000182450 KCNK4 / Q9NYG8 / potassium two pore domain channel subfamily K member 4  / complex
 ENSG00000100433 KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10  / complex






 

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