ENSG00000182450


Homo sapiens

Features
Gene ID: ENSG00000182450
  
Biological name :KCNK4
  
Synonyms : KCNK4 / potassium two pore domain channel subfamily K member 4 / Q9NYG8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64291302
Gene end: 64300031
  
Corresponding Affymetrix probe sets: 224552_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441460
Ensembl peptide - ENSP00000446454
Ensembl peptide - ENSP00000444948
Ensembl peptide - ENSP00000378033
Ensembl peptide - ENSP00000402797
NCBI entrez gene - 50801     See in Manteia.
OMIM - 605720
RefSeq - NM_033310
RefSeq - NM_001317090
RefSeq Peptide - NP_001304019
RefSeq Peptide - NP_201567
swissprot - Q9NYG8
swissprot - F5GYE0
swissprot - F5GZ20
swissprot - A0A024R5C7
Ensembl - ENSG00000182450
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk4aENSDARG00000103286Danio rerio
 Kcnk4ENSMUSG00000024957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10ENSG0000010043342
KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2ENSG0000008248238
KCNK17 / Q96T54 / potassium two pore domain channel subfamily K member 17ENSG0000012478028
KCNK5 / O95279 / potassium two pore domain channel subfamily K member 5ENSG0000016462626
KCNK6 / Q9Y257 / potassium two pore domain channel subfamily K member 6ENSG0000009933724
KCNK16 / Q96T55 / potassium two pore domain channel subfamily K member 16ENSG0000009598124
KCNK9 / Q9NPC2 / potassium two pore domain channel subfamily K member 9ENSG0000016942723
KCNK3 / O14649 / potassium two pore domain channel subfamily K member 3ENSG0000017130322
KCNK1 / O00180 / potassium two pore domain channel subfamily K member 1ENSG0000013575022
KCNK15 / Q9H427 / potassium two pore domain channel subfamily K member 15ENSG0000012424921
KCNK7 / Q9Y2U2 / potassium two pore domain channel subfamily K member 7ENSG0000017333820


Protein motifs (from Interpro)
Interpro ID Name
 IPR003280  Two pore domain potassium channel
 IPR008074  Two pore domain potassium channel, TRAAK
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0019233 sensory perception of pain ISS
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050951 sensory perception of temperature stimulus ISS
 biological_processGO:0050976 detection of mechanical stimulus involved in sensory perception of touch ISS
 biological_processGO:0071260 cellular response to mechanical stimulus IDA
 biological_processGO:0071398 cellular response to fatty acid IDA
 biological_processGO:0071469 cellular response to alkaline pH ISS
 biological_processGO:0071502 cellular response to temperature stimulus ISS
 biological_processGO:0071805 potassium ion transmembrane transport IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034705 potassium channel complex IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity TAS
 molecular_functionGO:0022841 potassium ion leak channel activity IBA
 molecular_functionGO:0097604 temperature-gated cation channel activity ISS
 molecular_functionGO:0098782 mechanosensitived potassium channel activity IDA


Pathways (from Reactome)
Pathway description
TWIK related potassium channel (TREK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100433 KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10  / complex
 ENSG00000082482 KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2  / complex
 ENSG00000182450 KCNK4 / Q9NYG8 / potassium two pore domain channel subfamily K member 4  / complex






 

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