ENSG00000099337


Homo sapiens

Features
Gene ID: ENSG00000099337
  
Biological name :KCNK6
  
Synonyms : KCNK6 / potassium two pore domain channel subfamily K member 6 / Q9Y257
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 38319844
Gene end: 38332076
  
Corresponding Affymetrix probe sets: 223658_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263372
NCBI entrez gene - 9424     See in Manteia.
OMIM - 603939
RefSeq - XM_011527526
RefSeq - NM_004823
RefSeq Peptide - NP_004814
swissprot - Q9Y257
swissprot - B2RDS2
Ensembl - ENSG00000099337
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk6ENSDARG00000007383Danio rerio
 Kcnk6ENSMUSG00000046410Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNK1 / O00180 / potassium two pore domain channel subfamily K member 1ENSG0000013575042
KCNK7 / Q9Y2U2 / potassium two pore domain channel subfamily K member 7ENSG0000017333832
KCNK4 / Q9NYG8 / potassium two pore domain channel subfamily K member 4ENSG0000018245030
KCNK5 / O95279 / potassium two pore domain channel subfamily K member 5ENSG0000016462627
KCNK17 / Q96T54 / potassium two pore domain channel subfamily K member 17ENSG0000012478027
KCNK16 / Q96T55 / potassium two pore domain channel subfamily K member 16ENSG0000009598127
KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2ENSG0000008248226
KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10ENSG0000010043326
KCNK3 / O14649 / potassium two pore domain channel subfamily K member 3ENSG0000017130324
KCNK15 / Q9H427 / potassium two pore domain channel subfamily K member 15ENSG0000012424924
KCNK9 / Q9NPC2 / potassium two pore domain channel subfamily K member 9ENSG0000016942724


Protein motifs (from Interpro)
Interpro ID Name
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005408  Two pore domain potassium channel, TWIK family
 IPR005409  Two pore domain potassium channel, TWIK-2
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0060075 regulation of resting membrane potential IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity TAS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity TAS
 molecular_functionGO:0022841 potassium ion leak channel activity IBA


Pathways (from Reactome)
Pathway description
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099337 KCNK6 / Q9Y257 / potassium two pore domain channel subfamily K member 6  / complex






 

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