ENSG00000135750


Homo sapiens

Features
Gene ID: ENSG00000135750
  
Biological name :KCNK1
  
Synonyms : KCNK1 / O00180 / potassium two pore domain channel subfamily K member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.2
Gene start: 233614004
Gene end: 233672512
  
Corresponding Affymetrix probe sets: 1566464_at (Human Genome U133 Plus 2.0 Array)   1566465_at (Human Genome U133 Plus 2.0 Array)   204678_s_at (Human Genome U133 Plus 2.0 Array)   204679_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355580
Ensembl peptide - ENSP00000409626
NCBI entrez gene - 3775     See in Manteia.
OMIM - 601745
RefSeq - NM_002245
RefSeq Peptide - NP_002236
swissprot - A0A024R3T2
swissprot - O00180
swissprot - Q5T5E6
Ensembl - ENSG00000135750
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk1aENSDARG00000045067Danio rerio
 kcnk1bENSDARG00000017254Danio rerio
 KCNK1ENSGALG00000011005Gallus gallus
 Kcnk1ENSMUSG00000033998Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNK6 / Q9Y257 / potassium two pore domain channel subfamily K member 6ENSG0000009933739
KCNK7 / Q9Y2U2 / potassium two pore domain channel subfamily K member 7ENSG0000017333836
KCNK10 / P57789 / potassium two pore domain channel subfamily K member 10ENSG0000010043328
KCNK2 / O95069 / potassium two pore domain channel subfamily K member 2ENSG0000008248226
KCNK4 / Q9NYG8 / potassium two pore domain channel subfamily K member 4ENSG0000018245025
KCNK3 / O14649 / potassium two pore domain channel subfamily K member 3ENSG0000017130324
KCNK16 / Q96T55 / potassium two pore domain channel subfamily K member 16ENSG0000009598124
KCNK9 / Q9NPC2 / potassium two pore domain channel subfamily K member 9ENSG0000016942724
KCNK5 / O95279 / potassium two pore domain channel subfamily K member 5ENSG0000016462623
KCNK15 / Q9H427 / potassium two pore domain channel subfamily K member 15ENSG0000012424923
KCNK17 / Q96T54 / potassium two pore domain channel subfamily K member 17ENSG0000012478021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001779  Two pore domain potassium channel, TWIK-1
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005408  Two pore domain potassium channel, TWIK family
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035725 sodium ion transmembrane transport IDA
 biological_processGO:0060075 regulation of resting membrane potential IMP
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0008076 voltage-gated potassium channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0034705 potassium channel complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:1902937 inward rectifier potassium channel complex IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity TAS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022841 potassium ion leak channel activity IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135750 KCNK1 / O00180 / potassium two pore domain channel subfamily K member 1  / complex






 

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