ENSMUSG00000033998


Mus musculus

Features
Gene ID: ENSMUSG00000033998
  
Biological name :Kcnk1
  
Synonyms : Kcnk1 / O08581 / Potassium channel subfamily K member 1
  
Possible biological names infered from orthology : O00180 / potassium two pore domain channel subfamily K member 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 125995170
Gene end: 126030685
  
Corresponding Affymetrix probe sets: 10576581 (MoGene1.0st)   1448690_at (Mouse Genome 430 2.0 Array)   1455896_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148778
Ensembl peptide - ENSMUSP00000046103
NCBI entrez gene - 16525     See in Manteia.
MGI - MGI:109322
RefSeq - NM_008430
RefSeq - XM_006530716
RefSeq Peptide - NP_032456
swissprot - A0A1D5RMH2
swissprot - O08581
Ensembl - ENSMUSG00000033998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk1aENSDARG00000045067Danio rerio
 kcnk1bENSDARG00000017254Danio rerio
 KCNK1ENSGALG00000011005Gallus gallus
 KCNK1ENSG00000135750Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*ENSMUSG0000004641038
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*ENSMUSG0000002493634
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*ENSMUSG0000003385427
Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*ENSMUSG0000003762426
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*ENSMUSG0000002338726
Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*ENSMUSG0000002495725
Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*ENSMUSG0000004926524
Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*ENSMUSG0000002324323
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSMUSG0000003676023
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*ENSMUSG0000003523822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001779  Two pore domain potassium channel, TWIK-1
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005408  Two pore domain potassium channel, TWIK family
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0060075 regulation of resting membrane potential IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:1902937 inward rectifier potassium channel complex IDA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IDA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0022841 potassium ion leak channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0010110 abnormal renal phosphate reabsorption "any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0011432 decreased urine flow rate "reduced volume of urine produced in a specified period of time" [MGI:anna]
Show

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033998 Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*  / complex






 

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