ENSMUSG00000024957


Mus musculus

Features
Gene ID: ENSMUSG00000024957
  
Biological name :Kcnk4
  
Synonyms : Kcnk4 / O88454 / Potassium channel subfamily K member 4
  
Possible biological names infered from orthology : potassium two pore domain channel subfamily K member 4 / Q9NYG8
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6925710
Gene end: 6934515
  
Corresponding Affymetrix probe sets: 10465500 (MoGene1.0st)   1421419_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025908
NCBI entrez gene - 16528     See in Manteia.
MGI - MGI:1298234
RefSeq - XM_006526721
RefSeq - NM_008431
RefSeq - XM_006526718
RefSeq - XM_006526719
RefSeq - XM_006526720
RefSeq - XM_006526716
RefSeq - XM_006526717
RefSeq Peptide - NP_032457
swissprot - O88454
swissprot - Q0VD85
Ensembl - ENSMUSG00000024957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk4aENSDARG00000103286Danio rerio
 KCNK4ENSG00000182450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*ENSMUSG0000003385440
Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*ENSMUSG0000003762437
Kcnk16 / Q96T55* / potassium two pore domain channel subfamily K member 16*ENSMUSG0000002338726
Kcnk5 / potassium two pore domain channel subfamily K member 5 / O95279*ENSMUSG0000002324325
Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6*ENSMUSG0000004641022
Kcnk15 / potassium two pore domain channel subfamily K member 15 / Q9H427*ENSMUSG0000003523821
Kcnk9 / Q3LS21 / Potassium channel subfamily K member 9 / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSMUSG0000003676021
Kcnk3 / O35111 / Potassium channel subfamily K member 3 / O14649* / potassium two pore domain channel subfamily K member 3*ENSMUSG0000004926521
Kcnk1 / O08581 / Potassium channel subfamily K member 1 / O00180* / potassium two pore domain channel subfamily K member 1*ENSMUSG0000003399821
Kcnk7 / potassium two pore domain channel subfamily K member 7 / Q9Y2U2*ENSMUSG0000002493619


Protein motifs (from Interpro)
Interpro ID Name
 IPR003280  Two pore domain potassium channel
 IPR008074  Two pore domain potassium channel, TRAAK
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050951 sensory perception of temperature stimulus IMP
 biological_processGO:0050976 detection of mechanical stimulus involved in sensory perception of touch IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071469 cellular response to alkaline pH IEA
 biological_processGO:0071502 cellular response to temperature stimulus IEA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity ISO
 molecular_functionGO:0022841 potassium ion leak channel activity IBA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0097604 temperature-gated cation channel activity IEA
 molecular_functionGO:0098782 mechanosensitived potassium channel activity IEA


Pathways (from Reactome)
Pathway description
TWIK related potassium channel (TREK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024957 Kcnk4 / O88454 / Potassium channel subfamily K member 4 / Q9NYG8* / potassium two pore domain channel subfamily K member 4*  / complex
 ENSMUSG00000037624 Kcnk2 / P97438 / Mus musculus potassium channel, subfamily K, member 2 (Kcnk2), transcript variant 5, mRNA. / O95069* / potassium two pore domain channel subfamily K member 2*  / complex
 ENSMUSG00000033854 Kcnk10 / potassium channel, subfamily K, member 10 / P57789* / potassium two pore domain channel subfamily K member 10*  / complex






 

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