ENSDARG00000021889


Danio rerio

Features
Gene ID: ENSDARG00000021889
  
Biological name :gja3
  
Synonyms : gap junction protein, alpha 3 / gja3
  
Possible biological names infered from orthology : Q64448 / Q9Y6H8
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 21407987
Gene end: 21409466
  
Corresponding Affymetrix probe sets: DrAffx.1.47.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000117213
NCBI entrez gene - 387533     See in Manteia.
swissprot - Q8JFD2
ZFIN ID - ZDB-GENE-031217-3
Ensembl - ENSDARG00000021889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GJA3ENSGALG00000017137Gallus gallus
 GJA3ENSG00000121743Homo sapiens
 Gja3ENSMUSG00000048582Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cx39.9 / connexin 39.9ENSDARG0000000408246
gja8b / gap junction protein alpha 8 paralog b / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000001507644
gja8a / gap junction protein alpha 8 paralog a / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000006945144
cx43 / O57474 / connexin 43ENSDARG0000004179940
gja5a / gap junction protein, alpha 5a / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000004006538
gja5b / gap junction protein, alpha 5b / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000006945038
cx34.5 / connexin 34.5ENSDARG0000006941137
cx40.8 / connexin 40.8 / GJA1* / P23242* / P17302* / gap junction protein alpha 1*ENSDARG0000007119235
cx52.6 / connexin 52.6 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000003493034
cx52.7 / connexin 52.7 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000005779234
cx52.9 / connexin 52.9 / GJA9* / P57773* / gap junction protein alpha 9*ENSDARG0000008645334
cx32.3 / connexin 32.3ENSDARG0000004178733
cx32.2 / Q7T047 / connexin 32.2ENSDARG0000007678933
cx28.9 / connexin 28.9ENSDARG0000004179732
cx39.4 / connexin 39.4 / GJA4* / P35212* / P28235* / gap junction protein alpha 4*ENSDARG0000007035730
cx43.4 / connexin 43.4ENSDARG0000000709929
cx28.1 / connexin 28.1ENSDARG0000004179229
cx47.1 / connexin 47.1 / GJC2* / Q8BQU6* / Q5T442* / gap junction protein gamma 2*ENSDARG0000007389629
cx44.2 / connexin 44.2 / si:dkey-91f15.8ENSDARG0000003420728
gjd2b / gap junction protein delta 2b / GJD2* / O54851* / Q9UKL4* / gap junction protein delta 2*ENSDARG0000007078126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002262  Gap junction alpha-3 protein (Cx46)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR031862  Gap junction alpha-5 protein (Cx40), C-terminal
 IPR034634  Connexin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003161 cardiac conduction system development IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0010644 cell communication by electrical coupling IMP
 biological_processGO:0048050 post-embryonic eye morphogenesis IMP
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0055077 gap junction hemi-channel activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle malformed , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart edematous , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium contractility , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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