ENSDARG00000071192


Danio rerio

Features
Gene ID: ENSDARG00000071192
  
Biological name :cx40.8
  
Synonyms : connexin 40.8 / cx40.8
  
Possible biological names infered from orthology : gap junction protein alpha 1 / GJA1 / P17302 / P23242
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 15413412
Gene end: 15417217
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124989
NCBI entrez gene - 565638     See in Manteia.
RefSeq - XM_688906
swissprot - E7FBZ4
ZFIN ID - ZDB-GENE-050616-10
Ensembl - ENSDARG00000071192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GJA1ENSGALG00000014873Gallus gallus
 GJA1ENSG00000152661Homo sapiens
 Gja1ENSMUSG00000050953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cx43 / O57474 / connexin 43ENSDARG0000004179970
gja3 / gap junction protein, alpha 3 / Q64448* / Q9Y6H8*ENSDARG0000002188943
cx39.9 / connexin 39.9ENSDARG0000000408240
gja8b / gap junction protein alpha 8 paralog b / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000001507640
cx32.3 / connexin 32.3ENSDARG0000004178739
gja8a / gap junction protein alpha 8 paralog a / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000006945139
cx34.5 / connexin 34.5ENSDARG0000006941138
gja5a / gap junction protein, alpha 5a / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000004006537
gja5b / gap junction protein, alpha 5b / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000006945036
cx52.6 / connexin 52.6 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000003493034
cx28.9 / connexin 28.9ENSDARG0000004179734
cx39.4 / connexin 39.4 / GJA4* / P35212* / P28235* / gap junction protein alpha 4*ENSDARG0000007035734
cx52.7 / connexin 52.7 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000005779233
cx32.2 / Q7T047 / connexin 32.2ENSDARG0000007678933
cx28.1 / connexin 28.1ENSDARG0000004179231
cx52.9 / connexin 52.9 / GJA9* / P57773* / gap junction protein alpha 9*ENSDARG0000008645331
cx47.1 / connexin 47.1 / GJC2* / Q8BQU6* / Q5T442* / gap junction protein gamma 2*ENSDARG0000007389630
cx43.4 / connexin 43.4ENSDARG0000000709929
cx44.2 / connexin 44.2 / si:dkey-91f15.8ENSDARG0000003420729
si:dkey-91f15.1ENSDARG0000009499028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002261  Gap junction alpha-1 protein (Cx43)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR034634  Connexin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IGI
 cellular_componentGO:0005921 gap junction IGI
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005243 gap junction channel activity IGI
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
Gap junction degradation
c-src mediated regulation of Cx43 function and closure of gap junctions
Formation of annular gap junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000071192 cx40.8 / connexin 40.8 / GJA1* / P23242* / P17302* / gap junction protein alpha 1*  / complex






 

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