ENSDARG00000011235


Danio rerio

Features
Gene ID: ENSDARG00000011235
  
Biological name :otx2b
  
Synonyms : orthodenticle homeobox 2b / otx2b / Q91981
  
Possible biological names infered from orthology : orthodenticle homeobox 2 / OTX2 / P32243
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 44244659
Gene end: 44249720
  
Corresponding Affymetrix probe sets: Dr.334.1.S2_at (Zebrafish Array)   NM_131251_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000111153
Ensembl peptide - ENSDARP00000128250
Ensembl peptide - ENSDARP00000020202
NCBI entrez gene - 30501     See in Manteia.
RefSeq - NM_131251
RefSeq - XM_005158883
RefSeq - XM_009293247
RefSeq Peptide - NP_571326
swissprot - Q1RM25
swissprot - Q91981
swissprot - X1WDF1
ZFIN ID - ZDB-GENE-980526-406
Ensembl - ENSDARG00000011235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTX2ENSGALG00000034889Gallus gallus
 OTX2ENSG00000165588Homo sapiens
 Otx2ENSMUSG00000021848Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
otx5 / orthodenticle homolog 5ENSDARG0000004348372
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499268
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070365
crx / cone-rod homeoboxENSDARG0000001198964
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992228
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251027
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619424
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660823
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006922
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397119
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925219
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202719
pax10 / paired box 10ENSDARG0000005336417
zgc:101100ENSDARG0000002195917
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003022  Transcription factor Otx2
 IPR003025  Transcription factor Otx
 IPR009057  Homeobox-like domain superfamily
 IPR013851  Transcription factor Otx, C-terminal
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003406 retinal pigment epithelium development IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0030902 hindbrain development IGI
 biological_processGO:0030917 midbrain-hindbrain boundary development IGI
 biological_processGO:0097306 cellular response to alcohol IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain increased distribution , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye perforate , abnormal
eye fused with eye , abnormal
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 ZFA:0000109 forebrain forebrain increased distribution , abnormal
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 ZFA:0000128 midbrain midbrain increased distribution , abnormal
midbrain decreased amount , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium ventral region absent , abnormal
retinal pigmented epithelium anterior side separated from retinal pigmented epithelium posterior side, abnormal
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 ZFA:0001064 rhombomere rhombomere increased distribution , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage shape , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton shortened , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001344 zona limitans intrathalamica zona limitans intrathalamica absent , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage orientation axis , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
pharyngeal arch cartilage disorganized , abnormal
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 ZFA:0001461 chondrocranium cartilage chondrocranium cartilage malformed , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage curved , abnormal
ceratobranchial cartilage shortened , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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