ENSDARG00000033971


Danio rerio

Features
Gene ID: ENSDARG00000033971
  
Biological name :prrx1a
  
Synonyms : paired related homeobox 1a / prrx1a
  
Possible biological names infered from orthology : P54821 / P63013 / Paired mesoderm homeobox protein 1 / paired related homeobox 1 / PRRX1
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 23165250
Gene end: 23172708
  
Corresponding Affymetrix probe sets: Dr.1410.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000041364
NCBI entrez gene - 406431     See in Manteia.
swissprot - Q7T373
ZFIN ID - ZDB-GENE-020905-5
Ensembl - ENSDARG00000033971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRRX1ENSGALG00000003324Gallus gallus
 PRRX1ENSG00000116132Homo sapiens
 Prrx1ENSMUSG00000026586Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202789
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619429
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251027
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006927
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660826
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992226
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499223
otx5 / orthodenticle homolog 5ENSDARG0000004348322
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070322
crx / cone-rod homeoboxENSDARG0000001198922
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123522
zgc:101100ENSDARG0000002195920
pax10 / paired box 10ENSDARG0000005336419
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907318
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart linear , abnormal
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 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm decreased distribution , abnormal
lateral plate mesoderm cell migration decreased occurrence , abnormal
lateral plate mesoderm right side mislocalised , abnormal
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 ZFA:0000154 sinus venosus sinus venosus absent , abnormal
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 ZFA:0000360 heart tube heart tube position , abnormal
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 ZFA:0000471 atrium atrium decreased size , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch ventral region amount , ameliorated
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage ventral region morphology , abnormal
pharyngeal arch cartilage ventral region amount , ameliorated
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 ventral region morphology , abnormal
pharyngeal arch 2 ventral region size , ameliorated
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 ventral region morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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