ENSDARG00000070069


Danio rerio

Features
Gene ID: ENSDARG00000070069
  
Biological name :pitx3
  
Synonyms : paired-like homeodomain 3 / pitx3 / Q6QU75
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 7555720
Gene end: 7575216
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000139963
Ensembl peptide - ENSDARP00000146864
Ensembl peptide - ENSDARP00000144770
Ensembl peptide - ENSDARP00000093314
NCBI entrez gene - 402974     See in Manteia.
RefSeq - NM_205675
RefSeq Peptide - NP_991238
swissprot - B2GRZ8
swissprot - A0A0R4ISS1
swissprot - Q6QU75
ZFIN ID - ZDB-GENE-041229-4
Ensembl - ENSDARG00000070069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000005613Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619470
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660860
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251028
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992226
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202723
otx5 / orthodenticle homolog 5ENSDARG0000004348323
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397123
crx / cone-rod homeoboxENSDARG0000001198922
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499222
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070322
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123522
zgc:101100ENSDARG0000002195917
pax10 / paired box 10ENSDARG0000005336417
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925216
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR016233  Homeobox protein Pitx/unc30
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0035270 endocrine system development IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0070306 lens fiber cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000101 diencephalon diencephalon has fewer parts of type dopaminergic neuron , abnormal
diencephalon dopaminergic neuron disorganized , abnormal
diencephalon lacks all parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000107 eye eye lacks all parts of type lens , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer has fewer parts of type amacrine cell , abnormal
retinal inner nuclear layer lacks all parts of type amacrine cell , abnormal
Show

 ZFA:0000418 pretectum pretectum has fewer parts of type dopaminergic neuron , abnormal
pretectum lacks all parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head deformed , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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