ENSDARG00000036194


Danio rerio

Features
Gene ID: ENSDARG00000036194
  
Biological name :pitx2
  
Synonyms : paired-like homeodomain 2 / pitx2 / Q9W5Z2
  
Possible biological names infered from orthology : P97474 / paired-like homeodomain transcription factor 2 / Q99697
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 36218072
Gene end: 36231211
  
Corresponding Affymetrix probe sets: Dr.8202.2.S1_a_at (Zebrafish Array)   NM_130975_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000156780
Ensembl peptide - ENSDARP00000052568
Ensembl peptide - ENSDARP00000120155
Ensembl peptide - ENSDARP00000149868
NCBI entrez gene - 30164     See in Manteia.
RefSeq - NM_130975
RefSeq Peptide - NP_571050
swissprot - Q9W5Z2
ZFIN ID - ZDB-GENE-990714-27
Ensembl - ENSDARG00000036194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PITX2ENSGALG00000042492Gallus gallus
 PITX2ENSG00000164093Homo sapiens
 Pitx2ENSMUSG00000028023Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006966
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660860
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251026
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992225
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397123
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202723
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123522
otx5 / orthodenticle homolog 5ENSDARG0000004348321
crx / cone-rod homeoboxENSDARG0000001198919
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070319
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499219
pax10 / paired box 10ENSDARG0000005336417
zgc:101100ENSDARG0000002195917
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925215
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR016233  Homeobox protein Pitx/unc30
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021501 prechordal plate formation IGI
 biological_processGO:0021538 epithalamus development IMP
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0035462 determination of left/right asymmetry in diencephalon IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043114 regulation of vascular permeability IGI
 biological_processGO:0048382 mesendoderm development IDA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060325 face morphogenesis IMP
 biological_processGO:0060971 embryonic heart tube left/right pattern formation IDA
 biological_processGO:0061072 iris morphogenesis IMP
 biological_processGO:0061303 cornea development in camera-type eye IMP
 biological_processGO:0061386 closure of optic fissure IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system hemorrhagic , abnormal
Show

 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye shape , abnormal
eye hemorrhagic , abnormal
eye anterior-posterior axis decreased length , abnormal
eye dorsal-ventral axis decreased length , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer disorganized , abnormal
Show

 ZFA:0000152 retina retina shape , abnormal
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 ZFA:0000170 basibranchial basibranchial hypoplastic , abnormal
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 ZFA:0000172 branchial muscle branchial muscle absent , abnormal
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 ZFA:0000213 habenula habenula determination of left/right symmetry process quality , abnormal
Show

 ZFA:0000236 mandibular muscle mandibular muscle morphology , abnormal
Show

 ZFA:0000301 medial rectus medial rectus increased thickness , abnormal
medial rectus myofibril disorganized , abnormal
Show

 ZFA:0000303 female organism female organism absent , abnormal
Show

 ZFA:0000547 mouth mouth open , abnormal
Show

 ZFA:0000640 cornea cornea morphology , abnormal
cornea increased thickness , abnormal
Show

 ZFA:0001027 oral cavity oral cavity malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased length , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head malformed , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
trunk kinked , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001142 tooth 5V tooth 5V absent , abnormal
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 ZFA:0001143 tooth 4V tooth 4V incomplete structure , abnormal
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 ZFA:0001145 tooth 3V tooth 3V absent , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage shape , abnormal
Meckels cartilage hypoplastic , abnormal
Meckels cartilage position , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton malformed , abnormal
Show

 ZFA:0001238 iris iris morphology , abnormal
iris proximal region hemorrhagic , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch mislocalised ventrally , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton mislocalised ventrally , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch malformed , abnormal
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 ZFA:0001359 pineal complex pineal complex molecular quality , abnormal
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 ZFA:0001360 parapineal organ parapineal organ hyperplastic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage shape , abnormal
palatoquadrate cartilage hypoplastic , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage position , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage absent , abnormal
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 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer absent , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage hypoplastic , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage hypoplastic , abnormal
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 ZFA:0001521 ceratobranchial 5 cartilage ceratobranchial 5 cartilage lacks parts or has fewer parts of type ceratobranchial 5 primary tooth , abnormal
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 ZFA:0001683 corneal epithelium corneal epithelium disorganized , abnormal
corneal epithelium scalloped , abnormal
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 ZFA:0001687 corneal endothelium corneal endothelium absent , abnormal
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 ZFA:0005046 hyaloid vessel hyaloid vessel morphology , abnormal
hyaloid vessel disorganized , abnormal
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 ZFA:0005564 aqueous humor aqueous humor decreased volume , abnormal
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 ZFA:0005566 anterior segment eye anterior segment eye increased accumulation cell , abnormal
anterior segment eye structure , abnormal
anterior segment eye cell disorganized , abnormal
anterior segment eye malformed , abnormal
Show

 ZFA:0007057 ocular blood vessel ocular blood vessel has extra parts of type hyaloid vessel , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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