ENSDARG00000094992


Danio rerio

Features
Gene ID: ENSDARG00000094992
  
Biological name :otx1
  
Synonyms : orthodenticle homeobox 1 / otx1 / Q91994
  
Possible biological names infered from orthology : Homeobox protein OTX1 / P32242 / P80205
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 24318753
Gene end: 24324415
  
Corresponding Affymetrix probe sets: Dr.284.1.S1_a_at (Zebrafish Array)   Dr.284.2.A1_a_at (Zebrafish Array)   NM_131250_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000064082
Ensembl peptide - ENSDARP00000157164
NCBI entrez gene - 30500     See in Manteia.
RefSeq - NM_131250
RefSeq Peptide - NP_571325
swissprot - Q91994
ZFIN ID - ZDB-GENE-980526-400
Ensembl - ENSDARG00000094992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTX1ENSGALG00000028817Gallus gallus
 OTX1ENSG00000115507Homo sapiens
 Otx1ENSMUSG00000005917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070370
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123561
otx5 / orthodenticle homolog 5ENSDARG0000004348357
crx / cone-rod homeoboxENSDARG0000001198954
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992223
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251022
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006920
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619419
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660819
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202718
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397118
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925217
zgc:101100ENSDARG0000002195916
pax10 / paired box 10ENSDARG0000005336416
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003025  Transcription factor Otx
 IPR003026  Transcription factor Otx1
 IPR009057  Homeobox-like domain superfamily
 IPR013851  Transcription factor Otx, C-terminal
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003406 retinal pigment epithelium development IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0060875 lateral semicircular canal development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000107 eye eye perforate , abnormal
eye decreased size , abnormal
eye morphology , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased size , abnormal
forebrain morphology , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
Show

 ZFA:0000128 midbrain midbrain morphology , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium anterior side separated from retinal pigmented epithelium posterior side, abnormal
retinal pigmented epithelium ventral region absent , abnormal
Show

 ZFA:0000168 anterior macula anterior macula decreased distance posterior macula , abnormal
Show

 ZFA:0000217 inner ear inner ear lacks all parts of type lateral semicircular canal , abnormal
inner ear lacks all parts of type lateral crista , abnormal
inner ear morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism unbalanced , abnormal
whole organism anterior-posterior axis bent , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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