Manteia

ENSMUSG00000005917

Mus musculus

Features

Gene ID:	ENSMUSG00000005917

Biological name :	Otx1

Synonyms :	Homeobox protein OTX1 / Otx1 / P80205

Possible biological names infered from orthology :	orthodenticle homeobox 1 / P32242

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	A3.2
Gene start:	21994764
Gene end:	22002897

Corresponding Affymetrix probe sets:	10384615 (MoGene1.0st) 1437601_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000006071 Ensembl peptide - ENSMUSP00000134704 NCBI entrez gene - 18423 See in Manteia. MGI - MGI:97450 RefSeq - XM_017314338 RefSeq - NM_011023 RefSeq Peptide - NP_035153 swissprot - P80205 swissprot - Q5SS54 swissprot - G3V000 Ensembl - ENSMUSG00000005917

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
otx1	ENSDARG00000094992	Danio rerio
OTX1	ENSGALG00000028817	Gallus gallus
OTX1	ENSG00000115507	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Otx2 / orthodenticle homeobox 2 / P32243*	ENSMUSG00000021848	57
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*	ENSMUSG00000041578	39
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*	ENSMUSG00000028707	21
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*	ENSMUSG00000021506	20
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*	ENSMUSG00000025229	19
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*	ENSMUSG00000028023	19
Prrx2 / paired related homeobox 2 / Q99811*	ENSMUSG00000039476	17
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*	ENSMUSG00000044542	16
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*	ENSMUSG00000026586	16
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*	ENSMUSG00000026497	14
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*	ENSMUSG00000021095	13
Gsc2 / goosecoid homeobox 2 / O15499*	ENSMUSG00000022738	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR003025	Transcription factor Otx
IPR003026	Transcription factor Otx1
IPR009057	Homeobox-like domain superfamily
IPR013851	Transcription factor Otx, C-terminal
IPR017970	Homeobox, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0009952	anterior/posterior pattern specification	IGI
biological_process	GO:0022037	metencephalon development	IGI
biological_process	GO:0030900	forebrain development	IGI
biological_process	GO:0030901	midbrain development	IGI
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048852	diencephalon morphogenesis	IGI
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd
MP:0000036	absent semicircular canals	"missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000104	abnormal sphenoid bone morphology	"malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tbx20^tm1.1Sev/Tbx20^tm1.1Sev Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx20^tm1.1Sev/Tbx20^tm1.1Sev Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000776	abnormal inferior colliculus	"dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000777	increased size of inferior colliculus	"enlargement of the paired inferior eminence of the mesencephalic tectum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000815	abnormal ammon gyrus morphology	"malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000826	abnormal third ventricle morphology	"malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000847	abnormal metencephalon morphology	"any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Otx1^tm1Asim/Otx1^tm2(otd)Asim,Otx2^tm1Pas/Otx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm2(otd)Asim,Otx2^tm1Pas/Otx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim,Otx2^tm1Pas/Otx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000904	abnormal superior colliculus	"dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000905	increased size of superior colliculus	"enlargement of the paired superior eminence of the mesencephalic tectum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000906	abnormal mesencephalic trigeminal nucleus	"malformation or disorganization of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Otx2^tm1Sia/Otx2^tm5Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000948	nonconvulsive seizures	"seizures without uncontrolled motor activity, but with impairment of consciousness" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001061	abnormal oculomotor nerve morphology	"malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0001063	abnormal trochlear nerve morphology	"any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001130	abnormal ovarian folliculogenesis	"atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0001322	abnormal iris morphology	"structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0001329	retina hyperplasia	"greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0001347	absent lacrimal glands	"missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Lyst^bg-J/Lyst^bg-J Genetic Background: C57BL/6J-Lyst^bg-J/J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001746	abnormal pituitary secretion	"altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vcam1^tm2Flv/Vcam1^tm2Flv,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002683	delayed fertility	"ability to produce live offspring occuring at a later than expected age" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002730	head shaking	"compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]	Show Allelic Composition: Lyst^bg-J/Lyst^bg-J Genetic Background: C57BL/6J-Lyst^bg-J/J
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Arhgap6/Hccs/Mid1^tm1Hzo/Y Genetic Background: involves: 129S7/SvEvBrd
MP:0002892	reduced size of superior colliculus	"decreased size of the paired superior eminence of the mesencephalic tectum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0003161	absent lateral semicircular canal		Show Allelic Composition: Lyst^bg-J/Lyst^bg-J Genetic Background: C57BL/6J-Lyst^bg-J/J Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0003243	abnormal dopaminergic neuron morphology	"malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Arhgap6/Hccs/Mid1^tm1Hzo/Y Genetic Background: involves: 129S7/SvEvBrd
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0003877	abnormal serotonergic neuron morphology	"malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]	Show Allelic Composition: Arhgap6/Hccs/Mid1^tm1Hzo/Y Genetic Background: involves: 129S7/SvEvBrd
MP:0004162	abnormal mammilary body morphology	"any malformation or absence of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004261	abnormal embryonic neuroepithelium morphology	"any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx2^tm1Sia/Otx2^tm10Sia Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004280	abnormal oculomotor nucleus morphology	"any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004450	presphenoid bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004457	abnormal orbitosphenoid bone morphology	"any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004463	basisphenoid bone foramen	"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^tm4Sly/Gusb^tm4Sly Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005205	abnormal eye anterior chamber	"anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0005537	abnormal cerebral aqueduct	"anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0006089	abnormal saccule morphology	"malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Lyst^bg-J/Lyst^bg-J Genetic Background: C57BL/6J-Lyst^bg-J/J
MP:0006090	abnormal utricle morphology	"malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Lyst^bg-J/Lyst^bg-J Genetic Background: C57BL/6J-Lyst^bg-J/J
MP:0006100	abnormal tegmentum morphology	"any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^tm4Sly/Gusb^tm4Sly Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0006101	absent tegmentum	"absence or loss of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0006105	reduced tectum size	"reduced size of the rostral part of the midbrain roof" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]	Show Allelic Composition: Gusb^tm4Sly/Gusb^tm4Sly Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0006106	absent tectum	"absence or loss of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008283	small hippocampus	"reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0008540	abnormal cerebrum morphology	"any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0008881	absent Harderian gland	"absence of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [MESH:A13.445]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008914	enlarged cerebellum	"increased size of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0009038	decreased inferior colliculus size	"decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0009247	meteorism	"swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0009637	abnormal pretectal region morphology	"any structural anomaly of a narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light reflex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0010893	abnormal posterior commissure morphology	"any structural anomaly of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gusb^tm4Sly/Gusb^tm4Sly Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Otx1^tm1Asim/Otx1^tm2(otd)Asim,Otx2^tm1Pas/Otx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0011962	increased cornea thickness	"increased width of the cornea in the center plane" [MGI:csmith]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0012087	absent midbrain	"absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm5Sia/Otx2^tm5Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0012089	decreased midbrain size	"size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm2(Otx1)Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0012132	abnormal midbrain-hindbrain boundary morphology	"any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]	Show Allelic Composition: Otx1^tm4(cre)Asim/Otx1⁺,Otx2^tm6Asim/Otx2^tm6.1Asim Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm2(Otx1)Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0012267	abnormal red nucleus morphology	"any anomaly of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [MGI:anna]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0012517	absent diencephalon	"absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]	Show Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm5Sia/Otx2^tm5Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0012525	abnormal rhombic lip morphology	"any structural anomaly of the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" [MGI:anna]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0012786	increased rhombomere 1 size	"increased size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm2(Otx1)Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0014165	absent ciliary process	"absence or loss of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; ciliary processes produce aqueous humor" [MGI:Anna]	Show Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim Genetic Background: involves: 129P2/OlaHsd
MP:0020527	small thalamus	"decreased size of the thalamus" [MGI:smb]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia,Otx1^tm1Sia/Otx1^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0020531	increased cerebellar foliation	"the cerebellar lobules are increased in size or number" [MGI:smb]	Show Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0020534	increased pons size	"increased size of or number of the nerve fibers in the pons" [MGI:smb]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia,Otx2^tm8.2Sia/Otx2^tm8.2Sia Genetic Background: involves: C57BL/6 * CBA
MP:0020543	decreased substantia nigra size	"decreased size of the substantia nigra" [MGI:smb]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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